肝细胞再生磷酸酶-3在肿瘤中的研究进展  

Research progress of phosphatase of regenerating liver-3 in tumors

作　　者：孙燕洁[1] 张闯[1] 

机构地区：[1]蚌埠医学院附属解放军第八二医院肿瘤科,江苏淮安223001

出　　处：《肿瘤研究与临床》2014年第10期713-716,共4页Cancer Research and Clinic

摘　　要：肝细胞再生磷酸酶-3（PRL-3）属于蛋白酪氨酸磷酸酶家族的成员,自2001年研究者通过SAGE技术首先发现其在结肠癌肝转移患者中存在高表达后,又进一步在乳腺癌、前列腺癌、肝癌、胃癌、肺癌、肾癌等肿瘤中检测出PRL-3高表达.文章就PRL-3与肿瘤发生及转移的相关性作一综述.Phosphatase of regenerating liver-3 （PRL-3） is one of member in the protein tyrosine phosphatase （PTP） family.Since high expression of PRL-3 was first discovered in liver metastasis patients with colon cancer,many researchers found that PRL-3 also high expressed in multiple organs like cancer from breast,prostate,liver,stomach,lung,kidney and so on.This paper focused on correlation of PRL-3 with the occurrence and metastasis of tumors.

关 键 词：肿瘤 肝细胞再生磷酸酶-3 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]