同步放化疗加巩固化疗方案治疗非小细胞肺癌的疗效  

Clinical efficacy of concurrent chemoradiotherapy followed by consolidation chemotherapy in the treatment of non-small cell lung cancer

作　　者：徐辉[1] 郭瑞祥[1] 秦文娟[1] 郦守国[1] 侯如蓉[1] 吴辉塔[1] 肖莉[1] 

机构地区：[1]厦门大学附属中山医院放疗科,厦门361004

出　　处：《中国肿瘤临床与康复》2014年第11期1330-1333,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨同步放化疗加巩固化疗方案在非小细胞肺癌治疗中的临床应用价值。方法将85例Ⅲ期非小细胞肺癌(NSCLC)患者按照随机分层分组法分为观察组和对照组,对照组给予序贯放化疗方案,观察组给予同步放化疗加巩固化疗方案,观察两组临床症状改善情况、近期疗效、血清肿瘤标志物水平、1、3年生存率和中位生存时间。结果观察组患者临床症状改善情况及血清肿瘤标志物水平均优于对照组,差异有统计学意义(P<0.05)。观察组患者临床有效率和受益率均明显高于对照组,差异有统计学意义(P<0.05)。随访3年,观察组和对照组1年生存率的差异无统计学意义(P>0.05),但观察组3年生存率及中位生存时间均高于对照组,差异有统计学意义(P<0.05)。结论同步放化疗加巩固化疗能显著改善NSCLC临床症状,降低血清肿瘤标志物水平,提高近期疗效和远期生存率,在NSCLC治疗中有重要意义。Objective To explore the clinical efficacy of concurrent chemoradiotherapy followed by consolidation chemotherapy in the treatment of non-small cell lung cancer（NSCLC）.Methods According to a stratified randomization method,85 patients with stage III NSCLC patients were randomly divided into the observation group and the control group in Xiamen Zhongshan Hospital.The control group was given the sequential chemoradiotherapy and the observation group was treated with concurrent chemoradiotherapy followed by consolidation chemotherapy.The clinical symptoms,the clinical efficacy and the levels of serum tumor markers were observed.Results The observation group was significantly better than the control group in the levels of serum tumor markers and the improvement of clinical symptoms,and the difference between the two groups was significant（P 〈 0.05）.The observation group was significantly higher than the control group in the clinical effective rate and the clinical benefit rate（P 〈 0.05）.Follow up of 3 years,the1-year survival rate in the observation group and the control group had no significant difference（P 〉 0.05）,however,the observation group was significantly higher than the control group in the 3-year survival rates and the median survival time（P 〈 0.05）.Conclusion Concurrent chemoradiotherapy followed by consolidation chemotherapy could significantly improve the clinical efficacy and the prognosis,it has important clinical value in the treatment of NSCLC.

关 键 词：肺肿瘤 同步放化疗 临床疗效 

分 类 号：R734.2[医药卫生—肿瘤]