卵巢肿瘤中桩蛋白paxillin的表达及其临床意义  

Expression and clinical significance of paxillin in ovarian cancer

作　　者：赵姗姗[1] 李梦熊[2] 徐娟[1] 沈慧敏[1] 

机构地区：[1]中山大学附属第一医院妇产科,广州510080 [2]中山大学附属第三医院妇产科,广州510630

出　　处：《新医学》2014年第11期714-717,共4页Journal of New Medicine

基　　金：广东省科技计划项目(2011B031800056);广东省自然科学基金资助项目(S2012010006150)

摘　　要：目的探讨桩蛋白paxillin在卵巢肿瘤中的表达及其临床意义。方法收集70例卵巢肿瘤标本和30份正常卵巢组织标本,应用组织芯片技术和En Vision免疫组织化学染色法检测标本中paxillin蛋白的表达水平,同时分析paxillin表达水平与临床病理参数之间的关系。结果 paxillin蛋白在卵巢肿瘤组织中的阳性表达率明显高于正常卵巢组织(78.6%vs.26.7%,P<0.01),其阳性表达率在不同病理分级、临床分期、有无淋巴结转移等临床病理参数间比较差异有统计学意义(P均<0.05),但在不同年龄、病理组织学类型间比较差异无统计学意义(P均>0.05)。结论 paxillin蛋白表达异常可能与卵巢肿瘤的发生、发展有关,其表达异常可作为判断预后的参考指标之一。Objective To explore the expression and clinical significance of paxillin in human ovari- an cancer. Methods Seventy ovarian cancer and 30 normal ovary specimens were collected. The expression level of paxillin proteins was measured by tissue microarray technology and immunohistochemical staining using the EnVision system. The relationship between the expression of paxillin and clinicopathological indexes was analyzed. Results The positive rate of paxillin protein was 78. 6% in the ovarian cancer samples, significant- ly higher compared with 26. 7% in the normal ovary （P 〈 0. 01 ）. The expression of paxillin was closely corre- lated with histological grade, clinical stage and lymph node metastasis （ all P 〈 0.05 ）, rather than age and pathological type （ both P 〉 0. 05 ）. Conclusions Abnormal expression of paxillin proteins may be associated with the incidence and development of ovarian tumors. And it may be used as one of reference markers for clin- ical prognosis.

关 键 词：卵巢肿瘤 组织芯片 免疫组织化学 桩蛋白 

分 类 号：R737.31[医药卫生—肿瘤]