文拉法辛与氟西丁治疗抑郁  

作　　者：靳自斌 左晓伟 邹扬 万礼霞[2] 胡存昆[2] 

机构地区：[1]江苏徐州市东方人民医院,徐州221004 [2]徐州市中心医院

出　　处：《国际精神病学杂志》2014年第4期196-198,共3页Journal Of International Psychiatry

摘　　要：目的探讨文拉法辛和氟西汀治疗抑郁障碍患者的疗效、残留症状与复发情况。方法将70例首发抑郁症患者随机分为文拉法辛(A)组和氟西汀组(B)组观察8周、随访一年。采用汉密尔顿抑郁量表作为评定指标分别于治疗前后评定疗效,随访观察持续疗效和残留症状。结果文拉法辛组治疗第一周及第八周汉密尔顿抑郁量表评分均显著低于对照组(P<0.01);一年随访时残留症状尤其是躯体症状、胃肠道、焦虑和睡眠障碍显著低于氟西汀组(P<0.05),临床治愈率高于氟西丁组(P<0.05)。结论文拉法辛治疗抑郁症疗效显著,起效快,残留症状少,复发率低。Objective To explore the eft residual symptoms venlafaxine and fluoxetine depressive disor- der. Method 70 first-episode depression patients were randomly divided into venlafaxine （ group A） and fluoxe- tine group （group B） observed 8 weeks, follow-up one year. Hamilton depression rating scale evaluated pretherapy and post-treatment, followed for effects residual symptoms. Result he scores of Hamilton depression rating scale of Venlafaxine treatment group were significantly lower than the control group in the first week and the eighth weeks （P〈0. 01 ） Residual symptoms especially somatic symptoms at the time of follow-up one year, gastrointestinal tract, anxiety and sleep disturbance lower than that of fluoxetine group （P〈0. 05） fluorine group （P〈0. 05） . Conclusion Venlafaxine rapid , less residual symptomslow recurrence rate

关 键 词：文拉法辛 氟西汀 抑郁障碍 残留症状 

分 类 号：R749.05[医药卫生—神经病学与精神病学]