胃癌中p-Stat3活化和SOCS3表达的临床病理意义及其对预后的影响  

Clinical pathological and prognostic significance of activated p-Stat3 and expressed SOCS3 in patients with gastric cancer

作　　者：陈海云[1] 张楠[1] 从丽[1] 陶林[1] 赵瑾[1] 李秀明[1] 张微[1] 张文杰[1] 

机构地区：[1]石河子大学医学院病理学系/地方与民族高发病教育部重点实验室,新疆石河子832002

出　　处：《重庆医学》2014年第32期4316-4319,共4页Chongqing medicine

基　　金：新疆研究生科研创新计划(XJGRI2013066);石河子大学绿洲学者基金(LZXZ201023)

摘　　要：目的探讨胃癌及癌旁组织中信号传导与转录激活因子3(Stat3)的活化及细胞因子信号转导抑制蛋白3(SOCS3)的表达水平对胃癌的发生、发展以及预后的影响。方法应用免疫组织化学Envision法检测53例胃癌以及其中27例相应癌旁组织中活化的Stat3(p-Stat3)的活化及SOCS3的表达水平,并结合患者的临床病理及随访资料进行分析。结果胃癌组织细胞核中p-Stat3的活化水平显著高于癌旁组织,细胞质中SOCS3的阳性表达明显低于非癌组织(P<0.05)。胃癌组织中p-Stat3活化水平与肿瘤浸润深度、分化程度和TNM分期呈明显正相关,SOCS3的表达与肿瘤浸润深度、TNM分期及淋巴结转移存在明显的负相关(P<0.05)。胃癌中p-Stat3活化水平与SOCS3表达水平呈明显负相关(r=-0.492,P<0.05)。Kaplan-Meier生存分析结果显示,p-Stat3的活化水平与患者生存率呈显著负相关(χ2=-5.05,P<0.05);相反,SOCS3表达水平则与患者生存率呈显著正相关(χ2=10.852,P<0.05)。结论 p-Stat3水平增高及负调节分子SOCS3的表达减少可能参与胃癌的发生、发展,可为评估胃癌预后的潜在临床指标。Objective To investigate the levels of activated Stat3（p-Stat3）and the expression levels of SOCS3 as well as their clinical significance and its impact on the pathogenesis,progression,and prognosis in patients with gastric cancer.Methods The levels of p-Stat3 and SOCS3were tested in 53 cases of gastric cancer tissues（test group）and 27 cases of adjacent non cancerous tissues（control group）by immunohistochemistry（IHC）.The clinical pathological and follow up data were analyzed.Results The levels of activated p Stat3 were significantly higher in gastric cancer tissues than in non cancerous tissues.The levels of SOCS3 were lower in cancer tissues than in non cancerous control tissues（P〈0.05）.p-Stat3 showed significantly different levels among TNM stages and tumor differentiation,and the expression levels of SOCS3 were negatively associated with cancer invasion,lymph node metastasis and TNM stages in cancer patients（P〈0.05）.Furthermore,a negative correlation was observed between the levels of activated p-Stat3 and SOCS3in gastric cancer tissues（r=-0.492,P〈0.05）.Kaplan Meier survival analyses indicated that the ptat3 levels were negatively correlated with total survival of gastric cancer patients,the higher the levels of p-Stat3 was,the lower the total survival rate would be（χ2=-5.05,P〈0.05）.On the contrary,the levels of SOCS3 showed a positive correlation with total survival（χ2=10.852,P〈0.05）.Conclusion Increased a p-Stat3 and decreased expression of negative Stat3 regulator SOCS3may play important roles in the development and progression of gastric cancer,both of which would potentially serve as prognostic markers for gastric cancer.

关 键 词：胃肿瘤 信号传导与转录激活因子3 细胞因子信号转导抑制蛋白3 癌症发生 癌症生存 

分 类 号：R735.2[医药卫生—肿瘤]