A型肉毒毒素治疗脑卒中后上肢痉挛疗效观察  

Effect of Botulinum Toxin A on Spastic Upper Limbs Dysfunction Post Stroke

作　　者：卢金华[1,2] 夏敏[1,3] 戴清月 程熙[1] 赖靖慧[1] 

机构地区：[1]福建中医药大学附属康复医院神经康复科,福建省福州市350003 [2]福建中医药大学 [3]国家中医药管理局中医康复研究中心 [4]国家中医药管理局中医康复重点学科

出　　处：《医学理论与实践》2014年第19期2521-2522,共2页The Journal of Medical Theory and Practice

摘　　要：目的:探讨局部注射A型肉毒毒素(BTX-A)对脑卒中后痉挛性肘及手功能障碍的改善作用。方法:20例伴有上肢痉挛的患者在BTX-A治疗前及治疗后2周、4周和12周应用改良Ashworth量表(MAS)、Fugl-Meyer量表(FMA)、改良Barthel指数(MBI)进行评估。结果:治疗后MAS改善(P<0.05),改善于注射后2周稳定出现,并至少维持12周。FMA、MBI与治疗前比较无显著性差异(P>0.05)。结论:BTX-A局部注射可以改善脑卒中后上肢痉挛及部分功能。Objective：To evaluate the efficacy of botulinum toxin type A（BTX-A）in the treatment of upper limb muscle spasticity,especially hand function obstacle and elbow extension,caused by stroke.Methods：Muscle tone was assessed using the Modified Ashworth Scale（MAS）.Other outcome measures were the Fugl-Meyer assessment（FMA）and modified Barthel lndex（MBI）.20 patients were assessed at baseline and 2,4and 12 weeks after treatment.Results：The scores of MAS improved after treatment（P〈0.05）,from 2weeks to 12 weeks.No significant improvement was observed in FMA and MBI（P〉0.05）.Conclusion：Local BTX-A injection can reduce the spasticity,and improve function of upper limbs for stroke patients.

关 键 词：脑卒中 痉挛 上肢 A型肉毒毒素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]