582例炎琥宁注射剂不良反应文献分析  

Literature Review of 582 Adverse Reaction Cases Induced by Potassium Sodium Dehydroandrographolide Succinate Injection

作　　者：丁伟 程刚[2] 董铎[2] 韩文敏[3] 吴桂芝[2] 

机构地区：[1]常州市武进区药品不良反应监测中心,江苏常州213000 [2]国家药品不良反应监测中心,北京100045 [3]常州市第二人民医院,江苏常州213000

出　　处：《中国药物警戒》2014年第11期675-678,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨炎琥宁注射剂致不良反应的一般规律和特点,寻找相关风险因素,为临床安全、合理用药提供参照。方法以"炎琥宁","不良反应"为检索词,检索中国期刊全文数据库,按纳入与排除标准共纳入53篇文献,进行资料的提取与统计分析。结果儿童患者发生率高,累及系统-器官主要为皮肤及其附件损害、全身性损害、呼吸系统损害等,不良反应以皮疹、发热、过敏反应等最为常见,严重可致过敏性休克。结论重视炎琥宁注射剂引起的不良反应,加强儿童用药监测,防范不良反应发生,确保临床用药安全。Objective Through investigating the characteristics and mechanism of adverse reactions induced by potassium sodium dehydroandrographolide succinate injection to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using＂potassium sodium dehydroandrographolide succinate＂ and ＂adverse reaction＂as key words to retrieve the CNKI database. Fifty-three articles which met the inclusion and exclusion criteria were extracted and analyzed. Results Pediatric patients appear to have higher ADR occurrence rate by using succinate injection. Systems and organs mainly involved in adverse reactions are skin and its appendages, systemic damage, respiratory damage, and etc. Rash, fever, and allergic reaction are the most common reported adverse reactions. Anaphylactic shock which is life threatening is also reported in several cases. Conclusion It is important to pay attention to the adverse reactions caused by potassium sodium dehydroandrographolidesuccinate injection, specially to strengthen pediatric postmarketing surveillance, in order to prevent adverse drug reactions and ensure the safe drug use in clinic.

关 键 词：炎琥宁注射剂 药品不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学]