前列腺癌根治术后是否立即辅助内分泌治疗的META分析  

Meta-analysis of the early versus delayed hormonal therapy of prostate cancer after radical prostatectomy

作　　者：高原[1] 韩邦旻[1] 梁胜杰[1] 邹青松[1] 夏术阶[1] 

机构地区：[1]上海交通大学附属第一人民医院泌尿外科,上海200080

出　　处：《国际泌尿系统杂志》2014年第6期861-864,共4页International Journal of Urology and Nephrology

摘　　要：目的 通过Meta分析对前列腺癌根治术后是否立即辅助内分泌治疗进行综合比较.方法 通过Pubmed、EMbase、Science Direct等数据库检索1990年至2013年相关文献.Jadad质量记分法评价纳入研究的质量,治疗组为前列腺癌术后立即给予内分泌治疗,对照组为前列腺癌术后延迟给予或不给予内分泌治疗,Meta分析评价两组总体生存率、肿瘤特异性生存率和无进展生存率.结果 5项研究入选,共4964例患者,分为治疗组2088例,对照组2876例.治疗组与对照组比较,总体生存率无统计学差异（P=0.71）,肿瘤特异性生存率（P＜0.0001）和无进展生存率（P＜0.0001）有统计学差异.结论 前列腺癌根治术后立即辅助内分泌治疗可以显著提高病人的肿瘤特异性生存率和无进展生存率,但不能提高总体生存率.Objectives To evaluate the efficacy of the early hormonal therapy of prostate cancer after radical prostatectomy through meta-analysis.Methods Related articles （from 1990 to 2013） were searched in Pubmed 、EMbase、Science Direct.The qualities of the included studies were evaluated by the Jadad scale.The treatment group means patients after radical prostatectomy were given immediate hormonal therapy,and the control group means patients after radical prostatectomy were given delayed hormonal therapy or no other therapy.Then we evaluated overall survival（OS）,cancer specific survival（CSS） and progression free survival（PFS） by meta-analysis.Results A total of 5 studies were adopted,and the total number of cases was 4964.There were 2088 cases in the treatment group and 2876 cases in the control group.Comparing control group with treatment group,there were no significant differences OS （P =0.71）,a great difference CSS （P ＜ 0.0001） and PFS （P ＜ 0.0001）.Conclusions Early hormonal therapy after radical prostatectomy can improve CSS and PFS,but cannot improve OS.

关 键 词：前列腺肿瘤 META分析 

分 类 号：R737.25[医药卫生—肿瘤]