首发精神分裂症患者治疗前后尿酸水平变化及其临床意义  

Change of uric acid levels of first -episode schizophrenia before and after treatment and its clinical significance

作　　者：程云[1] 陈雪菲[1] 薛永[1] 

机构地区：[1]江苏省淮安市第三人民医院,江苏淮安223001

出　　处：《中国伤残医学》2014年第24期30-32,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探讨165例首发精神分裂症患者治疗前后尿酸水平变化及临床意义。方法：选取165例临床确诊首发精神分裂症患者，并对165例患者治疗前及治疗后8周血清作尿酸检查，血清尿酸检测采用OLYMPUS640全自动生化分析仪检测，方法学为trinder反应终点法。选取614例健康人群做平行对照。结果：165例首发精神分裂症患者治疗前与治疗后比较，治疗后尿酸水平升高（t＝2．275，P＜0．05），治疗前与健康对照比较，患者组尿酸水平低于对照组（t＝7．83，P＜0．05），治疗8周后患者尿酸水平低于对照组（t＝4．93，P＜0．01）。结论：首发精神分裂症患者治疗后血清尿酸水平升高，可能与精神分裂症患者服药治疗相关。Objective：To investigate serum uric acid changes of first -episode schizophrenia after treatment and its clinical signifi-canceMethods：165 cases of first-episode schizophrenia were chosen for study on changes of uric acid.Serum uric acid were detected by olympus640 automatic chemical analyzer.614 serum samples of healthy controls were investigated as parallel group.Reasults：Serum uric acid of first -episode schizophrenia were increased significant after treatment compared with before treatment.,The increase of serum uric acid levels were more significant in femail group（P〈0.05）after treatment.There was no significant difference of the uric acid levels be-fore and after treatment.Conclusion：Elevated uric acid levels in schizophrenic patients with antipsychotic drug treatment.Determination of serum uric acid in the process of treatment of schizophrenia might help to understand the effect of drug on patients with uric acid metabo-lism, conduce to rehabilitation and treatment of schizophrenia patients.

关 键 词：精神分裂症 尿酸 

分 类 号：R749.3[医药卫生—神经病学与精神病学]