层层组装那他霉素微胶囊释放速率对抗光解的影响  

Effects of Release Rate for Natamycin Microcapsules from Layer-by-layer Assembly on Their Anti-photolysis

作　　者：肖俊俊[1] 卢向阳[2] 巨修练[1] 李川东[3] 

机构地区：[1]武汉工程大学化工与制药学院,武汉430074 [2]北京市农林科学院植物保护环境保护研究所,北京100097 [3]长江大学农学院,湖北荆州434023

出　　处：《农药》2014年第12期888-891,共4页Agrochemicals

基　　金：北京市自然科学基金资助项目(2122019)

摘　　要：[目的]研究层层组装那他霉素(NA)微胶囊的释放速率对抗光解性能的影响。[方法]采用抑菌圈法测定微胶囊的抗光解性能,HPLC法测定NA在水中的释放速率。[结果]3、7、11层和固化11层组装体的释放速率T10分别较NA原药降低0.47、1.17、1.79、2.81倍;在紫外光下,它们的相对活性下降50%的时间分别为38.24、58.95、67.47、75.26 min,较NA原药分别提高1.0、2.1、2.5、3.0倍。[结论]随着微胶囊组装层数的增加,组装体的释放速率显著下降,微胶囊的抗光解性能也明显提高。[Aims] Effects of release rate of natamycin（NA） microcapsules（MCs） prepared by layer-by-layer assembly（Lb L）on anti-photolysis performance were studied. [Methods] The anti-photolysis performance of the MCs was determined with inhibition zone, and NA release rate of MCs was analyzed in the water by HPLC. [Results] The release rates T10 of three layer, seven layer, eleven layer, crosslinking eleven layer assemblies were respectively decreased by 0.47, 1.17, 1.79 and 2.81 times than that of uncoated NA. The times for relative activity of MCs decreased by 50% under UV were 38.24, 58.95, 67.47, 75.26 min, respectively, which increased by 1.0, 2.1, 2.5, 3.0 times compared with uncoated NA. [Conclusions] With an increase of layer number for MCs, the release rate of the assemblies declines magnificently, meanwhile, the anti-photolysis performance of MCs improve obviously.

关 键 词：那他霉素 微胶囊 层层组装 控制释放 抗光解 

分 类 号：TQ455[化学工程—农药化工]