基于Granger因果分析研究颞叶癫痫脑电的网络特性  

Research on causal network characteristics of EEGs recording of patients with temporal lobe epilepsy by domain granger causality analysis

作　　者：裘志军[1,2] 陈旨娟[1,2] 田心[1] 

机构地区：[1]天津医科大学生物医学工程学院,天津300070 [2]天津医科大学总医院神经内科,天津300052

出　　处：《天津医科大学学报》2014年第6期437-440,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(91132722)

摘　　要：目的:从多通道脑电(EEG)的功能性连接和因果网络的角度,研究癫痫发作期过度放电的脑网络机制。方法:对16通道EEGs进行频域Granger因果分析,计算两个节点之间因果值γij,平均后得到DTF值。应用γij构建因果网络,计算BC度量值并进行K均值聚类分析,分析其变化趋势。计算发作期活跃节点因果流值以及间歇期、发作前期相对应节点的因果流值。结果:颞叶癫痫发作期能量分布优势频带是δ频段。δ频段DTF值:间歇期为7.340 4±1.962 9,发作前期为4.875 5±1.054 1,发作期为8.177±1.697 8,正常对照组为2.159 1±0.556 1。δ频段活跃节点BC度量值:间歇期为0.049 9±0.014 9,发作前期为0.046 9±0.009 5,发作期为0.080±0.020。δ频段发作期活跃节点因果流值为0.686 4±0.303 7,间歇期、发作前期相对应的区域因果流值为0.149 5±0.135 8、0.1174±0.0648。结论:颞叶癫痫组比正常对照组功能连接特性增强;颞叶癫痫发作期活跃节点BC度量值比间歇期、发作前期增大;颞叶癫痫发作期活跃节点属于因果源,非活跃节点属于因果汇。Objective： To analyze the excessive discharge of epilepsy by functional connectivity and causal network character of multichannel EEGs. Methods： EEGs of 16 channels were analyzed by frequency domain Granger causality. The γijof causal value between two nodes was calculated, and DTF value was obtained by average. Causal network was built to calculate the BC measurements. BC measurements were analyzed by K-means clustering to compare the change of BC measurements. Causal flow value of ictal periods was calculated, and causal flow values of the node corresponding in interictal and preictal period were compared. Results： The advantage of the energy distribution in ictal period of TLE was the delta frequency. The DTF value of delta frequency： interictal period 7.340 4 ±1.9629,preictal period 4.8755 ±1.0541, ictal period 8.177±1.6978, the normal group 2.1591±0.5561. Active nodes＇ BC measurements of delta frequency： interictal period 0.049 9±0.0149, preictal period 0.0469± 0.0095, ictal period 0.080±0.020. Active node＇s causal flow value of delta frequency： ictal period 0.686 4±0.3037, interictal and preictal period of the corresponding region： 0.1495±0.1358, 0.117 4±0.0648.Conclusion： The connecting function of TLE group is significantly enhanced, as compared to the normal control group. BC of active nodes in ictal period of TLE significantly increases, as compared to interictal and preictal period. Active nodes in ictal period of TLE are the causal source while inactive nodes in ictal period of TLE are the causal sinks.

关 键 词：颞叶癫痫 脑电 频域Granger因果分析 BC度量值 因果流 

分 类 号：R742.1[医药卫生—神经病学与精神病学]