tau蛋白与阿尔茨海默病的研究进展  

Advance in Relationship between Tau Protein and Alzheimer's Disease(review)

作　　者：胡江平[1] 耿瑞[1] 李凯军[1] 

机构地区：[1]牡丹江医学院,黑龙江牡丹江市157011

出　　处：《中国康复理论与实践》2014年第11期1031-1034,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：黑龙江省教育厅海外学人项目(No.1153h16);牡丹江医学院科技项目(No.ZS201329;No.ZS201303)

摘　　要：阿尔茨海默病(AD)的主要病理变化之一是神经元内出现以磷酸化tau蛋白为主要成分的神经原纤维缠结。以往研究主要集中在老年斑及Aβ层面,近年来的研究表明,tau蛋白与AD的发生发展有着密切联系,tau蛋白异常磷酸化已成为目前的研究热点。本文从蛋白激酶及磷酸酶角度对tau蛋白磷酸化与AD之间的关系进行综述。Alzheimer＇s disease is a common neurodegenerative disease. One of the main pathology is neurofibrillary tangles in neurons, in which principal component is the phosphorylation of tau protein. Previous studies focused on senile plaques and Aβlevels. Recent studies indicated that the development of tau protein closely associated with Alzheimer＆#39;s disease, especially the abnormal phosphorylation. This pa-per reviewed the relationship between tau protein phosphorylation and Alzheimer＆#39;s disease based on the perspective of protein kinases and phosphatases.

关 键 词：阿尔茨海默病 TAU蛋白 磷酸化 神经原纤维缠结 综述 

分 类 号：R749.1[医药卫生—神经病学与精神病学]