宫颈癌术后调强放射治疗配合同期化疗的临床观察  

Clinical observation of concurrent intensity modulated radiation therapy and chemotherapy in postoperative treatment of cervical cancer

作　　者：刘美莲[1] 赵博[1] 白雪[1] 黄辉[1] 何卓凯[1] 蔡锐[1] 

机构地区：[1]桂林医学院附属医院放疗科,广西桂林541001

出　　处：《华夏医学》2014年第5期4-8,共5页Acta Medicinae Sinica

基　　金：广西教育厅科研项目资助(201106LX361)

摘　　要：目的:探讨宫颈癌术后患者调强放射治疗配合同期化疗的临床疗效。方法:宫颈癌术后患者62例分为实验组32例釆用调强放射治疗;对照组30例釆用普通常规放疗。观察两组患者治疗效果及早期放化疗副反应的发生情况。结果:放疗后6个月实验组有效率为100.0%,对照组为96.7%,两组差异无统计学意义;两组下消化道、血液学的急性放射损伤严重程度差异无统计学意义;实验组皮肤、泌尿系急性放射损伤严重程度比对照组轻,差异有统计学意义(P<0.01,P<0.05)。结论:宫颈癌术后患者调强放射治疗配合同期化疗的近期疗效满意,可以减少急性放射性损伤,泌尿系统副反应较少,对放射区域的皮肤保护好。Objective：To investigate the clinical effect of concurrent intensity modulated radiation therapy and chemotherapy in postoperative treatment of cervical cancer.Methods：62patients of cervical cancer were divided into two groups.The experimental group included 32 cases who had undergone intensity modulated radiation therapy.The control group included 30 cases,who had undergone conventional radiotherapy.The differences in rate of early concurrent chemoradiation side effects and treatment effects were observed.Results：The efficacy was evaluated 6months after radiotherapy,effective rate was 100.0%in the experimental group and 96.7%in the control group,the difference had no statistical significance.The severity of acute radiation damage in gastrointestinal and hematology between the two groups had no statistical significance.The severity of acute radiation damage in skin and the urinary system in the experimental group was lower than control group,the difference was statistically significant（P〈0.01,P〈0.05）.Conclusion：Concurrent chemotherapy and intensity modulated radiation therapy for cervical cancer after surgery achieved a satisfactory effect.It could reduce acute radiation damage,with the less side effects at urinary system and was superiority at protection of the skin.

关 键 词：宫颈癌 调强放射治疗 放射治疗 化学治疗 副作用 

分 类 号：R737.33[医药卫生—肿瘤]