中高强度有氧运动干预阿尔茨海默病的临床研究  

Clinical Effects of Aerobic Exercises Training with Moderate and High Intensity in Alzheimer's Disease Treatment

作　　者：王英[1] 沈飞飞[1] 朱奕[2] 杨思雨[1] 李海燕[3] 汪琴[1] 王炜[1] 吴婷[1] 

机构地区：[1]南京医科大学第一附属医院神经内科,210029 [2]南京医科大学第一附属医院康复医学科,210029 [3]马鞍山市中心医院神经内科,243000

出　　处：《中国临床神经科学》2014年第5期504-509,共6页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金(编号:30901578);江苏省"六大人才高峰"第八批高层次人才资助项目;江苏省高校"青蓝工程"中青年学术带头人培养对象项目(编号:JX2161015003);江苏省卫生厅"科教兴卫工程"重点人才项目(编号:RC2011072);江苏省卫生厅"科教兴卫工程"开放课题(编号:XK20200905);苏州市科技局科技发展计划项目(编号:SYSD2011044)

摘　　要：目的探讨中高强度有氧运动疗法对阿尔茨海默病(AD)患者的干预作用。方法将52例AD患者分为中等强度有氧运动(中等强度)组(13例)、高强度有氧运动(高强度)组(13例)和对照组(26例)。所有入组患者均按AD常规治疗,中等强度组和高强度组分别接受强度为50%和70%最大运动能力的有氧运动训练12周,每周3次。于治疗前、治疗后8和12周对3组患者进行AD相关量表(MMSE、ADCS-ADL、NPI、NPI-D和ADAS-cog)评价,同时进行体格检查、血常规、血生化常规等检查。结果中等强度组、高强度组有氧运动能明显改善患者的认知能力和精神神经症状,与对照组比较差异有统计学意义(P<0.05);中等强度组和高强度组有氧运动对患者日常生活活动能力无有益影响。第8周,高强度组MMSE和NPI评分较中等强度组改善更多(P<0.05);而12周时,两组差异无统计学意义。结论有氧运动疗法可显著改善AD患者认知功能和精神神经症状,但对日常生活活动能力无影响;短期内高强度有氧运动较中等强度可能获益更多,长期则中等强度有氧运动与高强度的获益相似。Aim To evaluate the clinical efficacy of aerobic exercises training of different intensities in patients with Alzheimer＇s disease.Methods 52 patients with mild to moderate Alzheimer＇s disease were randomly allocated into 3 groups. Two exercise groups were treated with aerobic exercises training at 50% or 70% of maximal intensity for 12 weeks, respectively.The efficacy of aerobic exercises was evaluated by MMSE, ADCS-ADL, NPI, NPI-D, and ADAS-cog at baseline, the end of 8 weeks and the end of 12 weeks.Results Patients of the exercise groups got statistically significant improvement in MMSE, NPI, NPI-D and ADAS-cog Tests（P〈0.05）. However, aerobic exercises did not improve the ADCS-ADL（P〈0.05）. Patients with 70% of maximal intensity exercise got a better improvement of MMSE and NPI than the patients with 50% of maximal intensity exercise（P〈0.05） at the end of 8 weeks. However, 50% and 70% of maximalintensity provide similar effects at the end of 12 weeks.Conclusion Aerobic exercises can improve the cognitive and functional symptoms of AD patients, with acceptable safety and tolerance. Long term aerobic exercises with different intensity may provide similar benefit.

关 键 词：阿尔茨海默病 有氧运动 临床试验 

分 类 号：R742.5[医药卫生—神经病学与精神病学]