The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma  

作　　者：Maria Li Lung Arthur Kwok Leung Cheung Josephine Mun Yee Ko Hong Lok Lung Yue Cheng Wei Dai 

机构地区：[1]Department of Clinical Oncology and Center for Nasopharyngeal Carcinoma Research,University of Hong Kong

出　　处：《Chinese Journal of Cancer》2014年第11期556-568,共13页

基　　金：supported by the Research Grants Council Area of Excellence grant (AoE/M-06/08)

摘　　要：The interplay between host cell genetics and Epstein-Barr virus(EBV) infection contributes to the development of nasopharyngeal carcinoma(NPC). Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen(HLA) complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis.The interplay between host cell genetics and Epstein-Barr virus（EBV） infection contributes to the development of nasopharyngeal carcinoma（NPC）. Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen（HLA） complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis.

关 键 词：EB病毒 遗传因素 鼻咽癌 宿主 人类白细胞抗原 细胞遗传学 基因调控 细胞信号 

分 类 号：R739.63[医药卫生—肿瘤]