共同性外斜视眼外肌病理研究  

Pathological analysis of extraocular muscles for conjugate exotropia

作　　者：龚琦[1] 邵庆[1] 刘虎[1] 

机构地区：[1]江苏省人民医院眼科,中国江苏省南京市210029

出　　处：《国际眼科杂志》2014年第11期2096-2097,共2页International Eye Science

摘　　要：目的:探讨共同性外斜视内直肌的病理变化与斜视发现时间的关系。方法:对30例共同性外斜视患者行斜视矫正手术,术中将截除的内直肌用4%甲醛固定后送病理,在显微镜下观察眼外肌的组织结构,并进行HE和Masson染色。结果:共同性外斜视30例中,内直肌纤维大小不一、形态异常,数量减少,肌肉不同程度的纤维化,经Masson染色后发现,发现斜视较久患者组眼外肌肌纤维含量明显少于发现时间较短患者组(P<0.05)。结论:斜视的发生与眼外肌的结构异常有关,发现斜视时间较久的共同性外斜视比发现时间较短的共同性外斜视其眼外肌发生明显的纤维化,说明内直肌纤维化可能是外斜视形成的原因之一。随着斜视时间的延长,眼外肌纤维化程度加重。AIM： To find out the relationship between the pathological changes of medial rectus muscles and the occurrence of concomitant exotropia. METHODS： Thirty cases of concomitant exotropia patients were collected to conduct the plastic surgery for strabismus correction. Medial rectus amputated intraoperative were fixed with 4% formaldehyde and then sent to histologic examination. The organizational structure of extraocular muscles was observed, Hematoxylin eosin （HE） and Masson staining were conducted under microscope. RESULTS： In the 30 cases, medial rectus muscle fiber presented different sizes, abnormal morphology, number reducing, and the muscle showed varying degrees of fibrosis. After Masson staining, it was found that extraocular muscle fiber content of longer strabismus patients were significantly shorter than that of shorter strabismus patients （ P〈0.05）, CONCLUSION： The occurrence of concomitant exotropia is related with the abnormal structure of extraocular muscles,with higher extent of fibrosis of extraocular muscle in the long period of constant concomitant exotropia than in the late-onset concomitant exotropia. That means the fibrosis of medial rectus probably is the reason of concomitant exotropia. The extent of fiber degeneration change of concomitant exotropia increased with the occurrence of it.

关 键 词：外斜视 病理 眼外肌 

分 类 号：R779.6[医药卫生—眼科]