血脂与结直肠癌肝转移关系的临床研究  

Clinical study of serum lipid profile in colorectal cancer patients with liver metastases

作　　者：姚素萍[1] 刘业六[2] 潘晓芳[1] 梁勇[1] 王明山[1] 刘卫东[2] 

机构地区：[1]淮安市淮阴医院肿瘤内科,江苏淮安223300 [2]淮安市第一人民医院普外科,江苏淮安223300

出　　处：《现代肿瘤医学》2014年第12期2919-2921,共3页Journal of Modern Oncology

摘　　要：目的:检测结直肠癌患者的血脂水平,包括总胆固醇(TC)和甘油三酯(TG),探讨血脂异常与结直肠癌肝转移的关系。方法:收集本院282例结直肠癌患者的临床病理资料并检测空腹血脂水平。测定患者血清白蛋白和计算体重指数(BMI)评估患者的营养状态,对血脂等临床病理因素与结直肠癌肝转移的关系进行统计学分析。结果:结直肠癌肝转移患者的高胆固醇血症及高甘油三酯血症比率高于无肝转移者,差异有统计学意义(P<0.05)。多元Logistic回归分析显示,高胆固醇血症是结直肠癌发生肝转移的独立危险因素之一,而与高甘油三酯血症无关。结论:高胆固醇血症与结直肠癌肝转移相关,血脂水平的增高可能促进结直肠癌肝转移。Objective： To investigate whether colorectal cancer（ CRC） liver metastases was associated to serum lipid abnormalities,the serum lipid profile including total cholesterol（ TC） and triglycerides（ TG） were examined in CRC patients. Methods： The fasting serum lipids and clinicopathologic factors were analyzed in 282 CRC patients. To determine the nutritional status,the body mass index（ BMI） was calculated and serum albumin was measured. Univariate and multivariate analyses were carried out to investigate the association of serum lipid profile with liver metastases. Results： The rate of liver metastasis was significantly higher in CRC patients with hyperlipidemias（ P 0. 05）.Multivariate Logistic regression analysis showed that hypercholesterolaemia,but not hypertriglyceridaemia,was an independent risk factor for liver metastasis in CRC patients. Conclusion： Hypercholesterolaemia was significantly associated with liver metastases in CRC patients. Elevated serum lipid level may facilitate the liver metastasis in CRC patients.

关 键 词：血脂 结直肠癌 肝转移 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]