激素在低钾性周期性麻痹中作用机制的研究进展  

Effect of hormone in hypokalemic periodic paralysis and its potential mechanism

作　　者：徐宏燕[1] 姚合斌[1] 

机构地区：[1]海军总医院内分泌风湿免疫科,北京100048

出　　处：《转化医学杂志》2014年第6期381-384,共4页Translational Medicine Journal

基　　金：国家自然科学基金面上项目(81170800)

摘　　要：低钾性周期性麻痹是一组与钾离子代谢相关的疾病,发病机制目前未明。临床上表现为四肢对称性迟缓性瘫痪,伴肌张力减低,腱反射减弱或消失,严重者可致严重的心律失常、呼吸肌麻痹而危及生命。发作前常有明显诱因,发作时伴内源性激素水平的变化,如胰岛素、甲状腺素、肾上腺素等。作者对上述各激素在低钾性周期性麻痹发生中的作用及潜在机制进行综述。Hypokalemic periodic paralysis hypokalemic periodic paralysis( HOPP) is a disease with potassium ion metabolism,the pathogenesis is unclear. Clinical manifestations are symmetrical flaccid paralysis of limbs,hypotonia,tendon hyporeflexia or areflexia,severe cases can causes erious arrhythmias,respiratory muscle paralysis and even endanger life. Before the onset patients often have significant incentives changes of endogenous hormone levels during the attack,such as insulin,thyroxine,epinephrine. This paper is to review the role of the various hormones in the occurrence of HOPP and the underlying mechanism.

关 键 词：低钾性周期性麻痹 激素 作用机制 

分 类 号：R746.3[医药卫生—神经病学与精神病学]