Caspase-3和Maspin在结肠黏液腺癌中的表达  

Expression of Caspase-3 and Maspin in colonic mucinous adenocarcinoma

作　　者：张剑虹[1] 张飞[2] 张晓丽[3] 刘君超[1] 刘博[1] 

机构地区：[1]河北北方学院附属第一医院病理科,河北张家口075000 [2]河北北方学院附属第一医院放疗科,河北张家口075000 [3]河北北方学院生命科学研究中心,河北张家口075000

出　　处：《新乡医学院学报》2014年第11期899-901,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨结肠黏液腺癌中Caspase-3和Maspin的表达及其与临床病理特征的相关性。方法应用组织芯片技术及免疫组织化学方法检测79例结肠黏液腺癌组织和32例正常结肠黏膜中Caspase-3和Maspin的表达。结果 Caspase-3和Maspin在正常结肠黏膜组织中的阳性表达率高于结肠黏液腺癌组织,差异有统计学意义(P<0.01)。Caspase-3阳性表达与肿瘤分化程度、临床分期及淋巴结转移有关(P<0.05,P<0.01);与患者性别、年龄、肿瘤大小、肿瘤浸润深度无明显相关性(P>0.05)。Maspin阳性表达与肿瘤分化程度、淋巴结转移有关(P<0.01);与患者性别、年龄、肿瘤大小、肿瘤浸润深度及临床分期无明显相关性(P>0.05)。结论 Caspase-3和Maspin可能参与了结肠黏液腺癌的发生发展,可作为评估结肠黏液腺癌预后的指标。Objective To investigate the expression of Caspase-3 and Maspin in colonic mucinous adenocarcinoma and the correlation of their expression with clinicopathological features. Methods The expression of Caspase-3 and Maspin were detected in 32 cases of normal colon mucosa tissues and 79 cases of colonic mucinous adenocarcinoma by tissue chip and immunohistochemical methods. Results The positive expression rates of Caspase-3 and Maspin in colonic mucinous adenocarcinoma were significantly lower than those in normal colon mucosa tissue（P〈0. 01）. The positive expression rate of Caspase-3in colonic mucinous adenocarcinoma was related to histological differentiation,lymph node metastasis and clinical stage（ P〈0. 05,P〈0. 01）;and was not related to sex,age,tumor size,depth of invasion of tumor（ P〉0. 05）. The positive expression rate of Maspin was related to histological differentiation,lymph node metastasis（ P〈0. 01）;and was not related to sex,age,tumor size,depth of invasion of tumor and clinical stage（P〉0. 05）. Conclusion Caspase-3 and Maspin may be involved in the occurrence and development of colonic mucinous adenocarcinoma. They can be used to evaluate prognosis for colonic mucinous adenocarcinoma.

关 键 词：组织芯片 结肠黏液腺癌 CASPASE-3 MASPIN 

分 类 号：R735.3[医药卫生—肿瘤]