傅里叶变换红外光谱检测乳腺癌相关研究  

Fourier transform infrared spectroscopy in detection of breast cancer

作　　者：陈素菡 劳玮炜 徐早仙 刘清[2] 文欢[1] 邓红[1] 

机构地区：[1]浙江大学医学院基础医学系,浙江杭州310058 [2]浙江大学分析化学与应用医学研究所,浙江杭州310027

出　　处：《浙江大学学报（医学版）》2014年第4期494-500,共7页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(30870971);浙江省自然科学基金(LY12H16027)

摘　　要：乳腺癌是女性最常见的恶性肿瘤，早期乳腺癌检出率相对较低，而中晚期乳腺癌治愈率低。傅里叶变换红外光谱（FTIR）是一种新型的分子和代谢水平的疾病检测技术，可先于形态学改变发现肿瘤的发生，具有客观、无损、快速、自动化的优点。本文综述近20年来与乳腺癌相关的FTIR研究，重点介绍该领域的发展过程，总结相关实验技术、数据分析方法和乳腺癌组织的主要光谱学特征，提出FTIR应用于乳腺癌检测所面临的挑战和未来可能的发展方向。Breast cancer is the the disease is the leading cause of spectroscopy is a novel approach to most common cancer in women. Later diagnosis of poor prognosis. Fourier-transform infrared （FTIR） provide information about the molecular components and metabolic conditions of human tissue; therefore it can detect the early changes caused by cancer cells prior to histological manifestation. FTIR-based diagnosis is rapid, simple and label free, which meets the requirements of an automated and patient-friendly technique. The current article gives an overview of the experimental techniques, data analysis methods and spectral signatures of breast cancer in FTIR- based diagnosis, summarizes the present challenges by focusing on the history of FTIR spectroscopy in breast cancer since 1990s, and highlights some investigations that give a perspective of FTIR-based diagnosis.

关 键 词：乳腺肿瘤/诊断 谱学 傅里叶变换红外 综述 

分 类 号：R737.9[医药卫生—肿瘤] Q657.33[医药卫生—临床医学]