血清中INF-γ、MMP-9对多发性硬化患者病情及远期生活质量的影响  

Effects of serum INF-γ,MMP-9 on the condition of disease and long-term quality of life in patients with multiple sclerosis

作　　者：张晓明[1] 闫德棋 赵贺玲[2] 潘更毅 薛梅芳 文进[1] 

机构地区：[1]解放军第159医院神经内科,河南驻马店463008 [2]济南军区总医院神经内科,山东济南250031 [3]驻马店市中心医院神经内科,河南驻马店463000

出　　处：《河南医学研究》2014年第10期7-10,共4页Henan Medical Research

摘　　要：目的:观察血清中干扰素-γ(INF-γ)、基质金属蛋白酶-9(MMP-9)不同含量水平对多发性硬化间歇、发作期及远期生活质量的影响。方法:采用ELISA测定76例每次发作期入院第2天血清中INF-γ、MMP-9含量水平。以每例患者3 a内复发间歇期、发作期为观察统计指标,3 a后采用多发性硬化生活质量-54(MSQOL-54)、神经功能残疾量表(EDSS)进行评分。结果:MS患者血清中INF-γ、MMP-9含量水平越高,间歇期越短、发作期越长、MSQOL-54各项评分越低及EDSS评分越高(P<0.05)。结论:MS患者每次发作期血清中INF-γ、MMP-9含量水平越高,则发作频率增加,发作期越长,远期生活质量越差。Objective ： To observe the effects of serum interferon gamma （ INF-γ）, matrix metallo- proteinase-9 （MMP-9） on on the condition of disease and long-term quality of life in patients with multiple sclerosis. Methods： Serum INF-γ, MMP-9 of 76 patients with ictal multiple sclerosis on the second day in hospital were detected by ELISA. Relapse periods and ictal periods within 3 years were observed statistically with multiple sclerosis quality of life-54 （MSQOL-54） and neuro- logical disability scale（EDSS）. Results： The higher serum levels of INF-γ and MMP-9, the shorter intermittent periods, the longer the ictal periods, the lower the MSQOL-54 score and the higher EDSS score（P 〈0.05 ）. Conclusion： The higher the serum INF-γ and MMP-9 in ictal period of MS, the more the seizure frequency, the longer the attack period, and the worse the long-term quality of life.

关 键 词：多发性硬化 干扰素-Γ 基质金属蛋白酶-9 间歇期 多发性硬化生活质量-54 

分 类 号：R744.5[医药卫生—神经病学与精神病学]