Impact of vasculature damage on the outcome of spinal cord injury:a novel collagenase-induced model may give new insights into the mechanisms involved  

作　　者：Patrick Losey Daniel C.Anthony 

机构地区：[1]Experimental Neuropathology,Department of Pharmacology,University of Oxford,Oxford,UK

出　　处：《Neural Regeneration Research》2014年第20期1783-1786,共4页中国神经再生研究（英文版）

基　　金：supported by a grant from Medical Research Council,No.MRCG0300456

摘　　要：The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome. Vascular damage leads to de- creased blood flow to the cord and the release of potentially toxic blood-borne components. Here we consider the mechanisms that may be contributing to hemorrhage-induced damage and discuss the utility of a new model of spinal cord hemorrhage, which was urgently required as most of our current understanding has been extrapolated from intracerebral hemorrhage studies.The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome. Vascular damage leads to de- creased blood flow to the cord and the release of potentially toxic blood-borne components. Here we consider the mechanisms that may be contributing to hemorrhage-induced damage and discuss the utility of a new model of spinal cord hemorrhage, which was urgently required as most of our current understanding has been extrapolated from intracerebral hemorrhage studies.

关 键 词：spinal cord injury VASCULATURE hemorrhage animal model COLLAGENASE stereotaxic microinjection 

分 类 号：R651.2[医药卫生—外科学]