声脉冲辐射成像技术对乳腺肿块鉴别诊断的临床研究  

Investigation on the Application of Acoustic Radiation Force Impulse Imaging in the Differential Diagnosis of Breast Masses

作　　者：吴芳[1] 崔凤荣[1] 芦桂林[1] 杜婷婷[1] 刘文[1] 

机构地区：[1]石河子大学医学院第一附属医院功能科,新疆石河子832008

出　　处：《农垦医学》2014年第2期101-106,共6页Journal of Nongken Medicine

摘　　要：目的:探讨声脉冲辐射力成像(Acoustic Radiation Force Impulse,ARFI)技术在乳腺良恶性肿块鉴别诊断中的临床应用价值。方法:应用ARFI技术对81例患者共85个乳腺肿块进行声触诊组织成像(Virtual Touch Tissue Imaging,VTI)及声触诊组织量化(Virtual Touch Tissue Quantification,VTQ)检查,VTI对肿块硬度进行评分,VTQ测量乳腺肿块内部剪切波速度(Shear Wave Velocity,SWV),与术后病理结果对照,分析乳腺良、恶性组间的差异。结果:VTI评分及VTQ在乳腺良恶性组之间比较差异有统计学意义(0.001)。ROC曲线下面积分别为0.898±0.017[95%CI(0.865,0.931),=0.000],0.913±0.018[95%CI(0.878,0.947),=0.000],SWV为4.0m/s作为乳腺恶性结节的诊断截点,敏感性为97.2%,特异性为81%。VTI评分4分作为诊断乳腺恶性结节的截点敏感性为90%,特异性为70%。联合VTI评分及VTQ诊断的敏感性、特异性及准确性分别为92.3%、97.8%、95.2%。结论:ARFI技术通过定性及定量评价乳腺良恶性肿块的弹性成像,有助于乳腺良恶性肿块的鉴别诊断。Objective：To explore the clinical application value of Acoustic radiation force impulse （ARFI） technology in the differential diagnosis of benign and malignant breast masses. Methods：Eighty-one patients with 85 masses （39 malignant,46 benign）were studied with conventional ultrasound examination firstly, and then ARFI. Organization hardness score was evaluated by Virtual touch tissue imaging（VTI）, the shear wave velocity（SMV） of the tumors was measured by virtual touch tissue quantification （VTQ）. Measured result were compared with pathological results, drawed the ROC curve find the cut off value point of VTQ to predict breast cancer. The difference between benign and malignant masses was analyzed. Results：There was significant difference between benign and malignant groups （ 0.001）. Areas of ROC curve of VTI scores and VTQ was sepreately 0.898＆#177;0.017[95%CI（0.865,0.931）, =0.000] , 0.913±0.018 [95%CI （0.878,0.947）, =0.000]. The cut-off value of VTI scores and SMV in diagnosis of malignangt masses were 4 scores and 4m/s, sensitivity and specificity of diagnosing breast cancer of 4 scores and 90%,70%, 4m/s were 81%,97.2%. Sensitivity,specificity and accuracy of the combination of VTI scores and VTQ were 92.3%, 97.8%,95.2%. Conclusions：ARFI provides qualitative and quantitative elasticity measurements of breast masses which can help improve the differentiate benign from malignant masses.

关 键 词：乳腺肿块 弹性成像 声脉冲辐射力成像技术 

分 类 号：R737.9[医药卫生—肿瘤]