肿瘤坏死因子α在多发性硬化及髓鞘再生中的研究进展  

The Research Progress of Tumor Necrosis Factor Alpha in Multiple Sclerosis and Remyelination

作　　者：雷旭丹 徐菲[1] 李玉皓[1] 

机构地区：[1]南开大学医学院、天津市肿瘤微环境与神经血管调节重点实验室,300071

出　　处：《天津医药》2014年第11期1141-1143,共3页Tianjin Medical Journal

基　　金：国家科技支撑计划项目(2012BAI08B06);国家自然科学基金资助项目(81301080);教育部留学回国启动基金([2012]1707)

摘　　要：肿瘤坏死因子(TNF)-α是一种多向性细胞因子,存在可溶性和跨膜两种形式,分别结合肿瘤坏死因子受体(TNFR)1和TNFR2发挥功能。近年来研究发现,TNF-α/TNFR通路在多发性硬化的发生和髓鞘再生中发挥了重要作用。TNFR1通过死亡受体介导凋亡信号通路,导致少突胶质细胞及神经元的凋亡,从而引起髓鞘脱失等神经退行性改变。TNFR2通过一系列级联反应促进少突胶质细胞前体细胞的增殖以及分化,从而促进髓鞘的再生,在多发性硬化中有积极作用。Tumor necrosis factor （TNF）-αis a pleiotropic inflammatory cytokine, which is produced chiefly by activated macrophages. Two forms of TNF-α, soluble and transmembrane, can bind tumor necrosis factor receptor （TNFR） 1 or TNFR2, respectively. Recently, a concept has emerged that TNF-α/TNFR pathway plays an important role in the pathogenesis of multiple sclerosis and remyelination. TNFR1 induces death of oligodendrocytes via death receptor-mediated apoptosis, which leads to demyelination or other neurodegenerative changes. However, TNFR2 has a positive effect on multiple sclerosis. It facilitates the proliferation and differentiation of oligodendrocyte precursor cells, thus promoting remyelination.

关 键 词：肿瘤坏死因子Α 受体 肿瘤坏死因子 多发性硬化 髓鞘 髓鞘再生 综述 

分 类 号：R744.5[医药卫生—神经病学与精神病学]