乳腺癌中神经细胞黏附分子的表达及临床意义  

Expression of neural cell adhesion molecule in breast carcinoma and its clinical significance

作　　者：向亚莉[1] 吴永国[1] 欧湛赐 肖静[1] 

机构地区：[1]深圳市宝安区松岗人民医院病理科,广东深圳518105

出　　处：《中国医药科学》2014年第22期24-27,共4页China Medicine And Pharmacy

基　　金：广东省深圳市宝安区科技计划-社会公益(医疗卫生类)立项项目(20110475)

摘　　要：目的探讨神经细胞黏附分子(NCAM)在乳腺癌中的表达及临床意义。方法应用免疫组织化学方法检测NCAM在30例乳腺癌组织、癌旁组织及30例乳腺良性病变组织中的表达情况。应用酶联免疫吸附法(ELISA)测定NCAM在30例乳腺癌患者、30例乳腺良性病变患者及30例正常人群中的血清浓度并进行统计学分析。结果免疫组化结果:乳腺癌组织、癌旁组织及乳腺良性病变组织中NCAM阳性率分别为26.67%、3.33%、3.33%,NCAM在癌组织中表达明显高于癌旁组织及良性病变组织(P<0.0125),乳腺癌中有神经侵袭组的NCAM阳性率明显高于无神经侵袭组(P<0.05)。ELISA结果:乳腺癌患者的NCAM血清浓度均显著高于良性病变组及正常人群组(P<0.05)。结论神经细胞黏附分子在乳腺癌的发生发展中可能起到了重要作用。NCAM的高表达对于乳腺癌的神经侵袭和转移可能很重要。Objective To investigate the expression of neural cell adhesion molecule（NCAM） protein in breast carcinoma and its clinical significance. Methods The expression of NCAM protein was detected in 30 cases of breast cancerous tissues,paracancerous tissues and 30 cases of benign breast lesion tissues by Immunohistochemistry. The serum NCAM concentration in 30 patients with breast carcinoma,30 patients with benign breast disease and 30 cases of normal people was detected by enzyme linked immunosorbent assay（ELISA）. Results Immunohistochemistry analysis showed that the positive expression rate of NCAM in breast cancerous tissues,paracancerous tissues and benign breast lesions tissues were 26.67%,3.33%,3.33% respectively. The expression of NCAM protein in breast cancerous tissues was significantly higher than that in paracancerous tissues and in benign lesions tissues（P〈0.0125）. The positive expression rate of NCAM in neural invasion group of breast carcinoma was significantly higher than that in non neural invasion group（P〈0.05）. ELISA analysis showed that the serum NCAM concentration in breast carcinoma group were significantly higher than that in benign breast disease group and in normal group（P〈0.05）. Conclusion NCAM may play an important role in the occurrence and development of breast carcinoma. The high expression of NCAM may be very important for neural invasion and metastasis of breast carcinoma.

关 键 词：神经细胞黏附分子(NCAM) 乳腺癌 酶联免疫吸附法 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]