miR-148a在消化系恶性肿瘤中的研究进展  

Progresses in research of miR-148a in digestive system cancers

作　　者：敖建[1] 肖卫东[1] 

机构地区：[1]南昌大学第一附属医院普外科,江西省南昌市330006

出　　处：《世界华人消化杂志》2014年第32期4938-4942,共5页World Chinese Journal of Digestology

基　　金：江西省自然科学基金资助项目;No.2010GZY0316;江西省教育厅科学技术研究基金资助项目;No.GJJ14018~~

摘　　要：MicroRNAs(miRNAs)是一类非蛋白编码的短小RNA,目前已证实在多种恶性肿瘤的发生和进展中都存在异常表达.消化系恶性肿瘤是目前全球主要的疾病致死原因之一.miRNAs的发现为消化系恶性肿瘤的诊断和治疗提供了新的方向.近年来许多研究表明,miR-148a在多种消化系恶性肿瘤如胃癌、肝癌、胰腺癌及结直肠癌等中都存在异常表达下调,他以肿瘤抑制因子的身份在这些肿瘤的发生、发展中发挥重要作用.本文就miR-148a在消化系恶性肿瘤中的作用的研究进展作一综述.MicroRNAs （miRNAs） are a class of small non- protein-coding RNAs, which are often aberrantly expressed in the progression of various malig- nant tumors. Digestive system cancers are major causes of death all over the world. The finding of miRNAs provides a new direction for the di- agnosis and therapy of digestive system cancers. Recent studies have demonstrated that miR-148a is aberrantly down-regulated in various digestive system cancers, including gastric cancer, hepato- cellular cancer, pancreatic cancer and colorectal cancer. MiR-148a play a crucial role in the pro- gression of these tumors as a tumor suppressor gene. This article will review the progress in re- search of miR-148a in digestive system cancers.

关 键 词：miR-148a 消化系恶性肿瘤 

分 类 号：R735[医药卫生—肿瘤]