抗gp210抗体的表达与原发性胆汁性肝硬化关系的临床研究  

Clinical study on the correlation between the expression of anti-gp210 antibody and primary biliary cirrhosis

作　　者：陈刚[1] 许建明[1] 

机构地区：[1]安徽医科大学第一附属医院消化内科,合肥230022

出　　处：《安徽医科大学学报》2014年第12期1819-1821,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81070337)

摘　　要：收集108例原发性胆汁性肝硬化(PBC)患者,根据抗gp210抗体表达情况分成抗gp210抗体阳性组和抗gp210抗体阴性组。分析两组间与PBC临床表现、肝生化指标及其肝功能状态的关系。结果显示抗gp210抗体阳性率为44.4%(48/108),16例AMA-M2阴性的PBC患者中有9例(56.2%)抗gp210抗体阳性。黄疸、乏力的出现与抗gp210抗体的表达差异有统计学意义(P<0.05)。抗gp210抗体阳性组总胆红素、直接胆红素水平明显高于阴性组(P<0.05),Mayo评分高于阴性组(P<0.05)。108 cases of PBC patients who were treated in our hospital.According to the expression of anti-gp210 antibody,those patients were divided into positive anti-gp210 antibody group and negative group.Statistical analysis was performed to investigate the correlation between the expression of anti-gp210 antibody and with PBC clinical manifestions,liver,biochemical test and liver function between the two groups.In 108 patients of PBC,the positive rate of anti-gp210 antibody was 44.4％,whereas 9 patients showed positive anti-gp210 antibody among 16 PBC cases with negative AMA-M2 （56.2％）.The expression of anti-gp210 antibody with the appearance of jaundice and fatigue had statistical significance （P ＜0.05）.In anti-gp210 antibody positive group,the mean levels of serum TBIL,DBIL and Mayo score were higher than that in anti-gp210 antibody negative group （P ＜ 0.05）.It demonstrates that the anti-gp210 antibody in serum can not only help early diagnosis of AMA-M2 negative PBC cases,but also be helpful for clinical assessment and prognosis.It indicates that anti-gp210 antibody has a clinical application value in PBC.

关 键 词：原发性胆汁性肝硬化 抗gp210抗体 临床指标 相关性 

分 类 号：R575.22[医药卫生—消化系统]