食管鳞状细胞癌组织中S100A11、14-3-3的表达及临床意义  

Significance of expression of S100A11 and 14-3-3 proteins in esophageal squamous cell carcinoma

作　　者：张玉洁 杜强 朱丽娟[2] 张艳[3] 李晓梅[2] 蒲红伟[3] 陈晓[3] 

机构地区：[1]克孜勒苏自治州人民医院病理科,新疆维吾尔自治区阿图什市845350 [2]新疆医科大学厚博学院病理学教研室,新疆维吾尔自治区乌鲁木齐市830011 [3]新疆医科大学基础医学院病理学教研室,新疆维吾尔自治区乌鲁木齐市830011

出　　处：《世界华人消化杂志》2014年第30期4609-4614,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81360303~~

摘　　要：目的:研究食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)组织中S100A11、14-3-3的表达及其临床意义.方法:应用免疫组织化学SP法检测68例ESCC组织和48例癌旁切端正常食管组织,观察S100A11、14-3-3的表达,并应用统计学方法分析其表达与临床病理学指标的意义.结果:(1)ESCC组织中S100A11、14-3-3蛋白的阳性表达率分别为:55.9%(38/68)、69.1%(47/68).正常食管组织中阳性表达率分别为:25.0%(12/48)、33.3%(16/48),经比较差异均有统计学意义(P<0.05);(2)ESCC组织中S100A11在不同性别、年龄、民族、肿瘤大小及不同浸润深度组之间的表达差异无统计学意义(P>0.05);在不同分化程度、有无淋巴结转移及不同临床分期组之间的表达差异有统计学意义(P<0.05);(3)ESCC组织中14-3-3在不同性别、年龄、民族及不同肿瘤大小组之间的表达差异无统计学意义(P>0.05);在不同分化程度、不同浸润深度、有无淋巴结转移及不同临床分期组之间的表达差异有统计学意义(P<0.05).结论:提示S100A11、14-3-3在ESCC的发生和发展中可能起到一定作用.S100A11、14-3-3在不同分化程度、有无淋巴结转移及不同临床分期组之间的表达均有显著差异,提示S100A11、14-3-3可能对ESCC恶性程度判断有一定的指导意义.AIM： To determine the correlation between invasion, migration and prognosis of esophageal squamous cell carcinoma （ESCC） and expression of S100A11 and 14-3-3 proteins. METHODS： Sixty-eight previously untreated pa-tients who underwent surgical excision of ESCC were included. The expression of S100All and 14-3-3 proteins was examined immunohistochemically in formalin-fixed paraffin-embedded primary tissue specimens. The relationships between the expression of S100All and 14-3-3 proteins, the clinicopathologic features of ESCC, and the survival rate of ESCC patients were analyzed. The correlation between S100A11 and 14-3-3 protein expression in ESCC was also analyzed. RESULTS： The positive rates of S100A11 and 14-3-3 protein expression were significantly higher in ESCC than in normal esophageal tissues （55.9% vs 25.0%, 69.1% vs 33.3%, P 〈 0.05）. S100A11 expression showed no significant correlation with gender, age, ethnicity, tumor size or infiltration depth （P 〉 0.05）, but was significantly correlated with degree of differentiation, lymph node metastasis and clinical stage （P 〈 0.05）. 14-3-3 expression showed no significant correlation with gender, age, ethnicity, or tumor size （P 〉 0.05）, but was significantly correlated with degree of differentiation, depth of infiltration, lymph node metastasis and clinical stage （P 〈 0.05）. CONCLUSION： S100A11 and 14-3-3 may play a role in the occurrence and development of ESCC. The expression of S100A11 and14-3-3 is significantly related to tumor differentiation, lymph node metastasis and clinical stage, and they may be used to assess the malignant degree of ESCC.

关 键 词：食管鳞状细胞癌 S100A11 14-3-3 

分 类 号：R735.1[医药卫生—肿瘤]