妊娠肝内胆汁淤积的发病机制研究进展  

Research Advances in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy

作　　者：许芙蓉[1] 章建朝[1] 

机构地区：[1]重庆市江北区中医院妇产科,重庆400020

出　　处：《医学综述》2014年第22期4109-4111,共3页Medical Recapitulate

摘　　要：妊娠肝内胆汁淤积症(ICP)是妊娠期特有的症状,患者临床表现为血清胆酸升高以及皮肤瘙痒,同时伴有肝酶升高及黄疸症状。大部分患者症状发生在妊娠晚期,也有少部分患者发生在妊娠中期,分娩结束后症状自行缓解消失。ICP可导致胎儿出现早产,增加胎儿宫内窘迫症状发生风险及胎儿病死率。目前该疾病的发病机制尚不明确,可能与环境、雌激素、孕激素以及遗传因素有关。该文将对影响ICP发生的相关因素以及该病的发病机制予以综述。Intrahepatic cholestasis of pregnancy（ ICP） is a pregnancy-specific symptom,whose clinical manifestations include elevated serum bile acids and itchy skin,accompanied by increased liver enzymes levels and jaundice. Symptoms of most patients occur in late pregnancy,while symptoms of a few patients occur in the second trimester of pregnancy,and symptoms spontaneously disappear after childbirth. ICP may lead to preterm fetus,and increase the risk of fetal distress symptoms and fetal mortality. Currently the pathogenesis of the disease is not clear,but may be related to the environment,estrogen,progesterone,and genetic factors.Here is to make a review of the related factors and pathogenesis of ICP.

关 键 词：妊娠肝内胆汁淤积症 发病机制 胆汁酸 

分 类 号：R575[医药卫生—消化系统]