尼莫地平治疗自发性蛛网膜下腔出血后脑血管痉挛的临床进展  

Clinical Advances in Nimodipine Therapy for Cerebral Vasospasm after Subarachnoid Hemorrhage

作　　者：翁栩[1] 杨健[1] 

机构地区：[1]重庆市中医院神经内科,重庆400011

出　　处：《医学综述》2014年第22期4128-4131,共4页Medical Recapitulate

摘　　要：蛛网膜下腔出血是我国中老年人群中常见的脑血管疾病,其可引起脑血管痉挛,增加患者死亡风险。引起脑血管痉挛的重要因素是钙离子超载,通过抑制钙离子超载可有效改善血管痉挛症状。尼莫地平属于钙离子抑制剂,能有效预防及抑制血管痉挛发生。目前大量临床试验证实钙离子抑制剂对血管性痉挛具有较理想的治疗效果。该文将通过查阅文献对尼莫地平治疗蛛网膜下腔出血引发的脑血管痉挛的作用机制及临床疗效进行综述,旨在为临床同类疾病用药治疗提供指导。Subarachnoid hemorrhage（ SAH） is a common cerebrovascular disease among middle-aged and elderly people in China,it can cause cerebral vasospasm（ CVS） that will increase the mortality risk of patients. The key factor that causes CVS is calcium overload,inhibition of calcium overload can effectively improve the symptom of vasospasm. Nimodipine is an inhibitor of calcium,which can effectively prevent and inhibit vasospasm from occurring. A lot of current clinical trials have proved inhibitor of calcium has ideal curative effect on vasospasm. Here is to make a review of the mechanism and clinical efficacy of nimodipine in the treatment for CVS caused by SAH,in order to provide guidance for clinical treatment and medication for similar diseases.

关 键 词：蛛网膜下腔出血 脑血管痉挛 尼莫地平 

分 类 号：R743[医药卫生—神经病学与精神病学]