口服普萘洛尔治疗婴幼儿血管瘤的临床研究  

Clinical research on the effects of propranolol on infantile hemangiomas

作　　者：郭军[1] 王宇[2] 张毅[1] 余静[1] 刘亚琼[1] 谢坚[1] 

机构地区：[1]四川省绵阳市中心医院儿科,621000 [2]四川省绵阳市中心医院药剂科,621000

出　　处：《重庆医学》2014年第33期4464-4466,共3页Chongqing medicine

基　　金：四川省卫生厅科研课题(100320);绵阳市中心医院课题(2014YJ22)

摘　　要：目的：研究口服不同剂量普萘洛尔治疗不同类型婴幼儿血管瘤（I H ）的疗效及不良反应。方法150例I H患儿采用口服不同剂量普萘洛尔治疗，治疗前行相关检查排除服药禁忌证。分为低剂量组（1 mg · kg －1· d－1，45例）及高剂量组（2 mg·kg －1·d－1，95例），服药方式为在心电监护下，分2～3次于喂奶后30 min服用。住院观察6～24 h后出院，出院后每月返院复查，每月复查1次心电图及血常规，必要时行肺功能检查。结果普萘洛尔治疗草莓状IH效果优于扁平状IH ，深部IH疗效优于浅表IH ，低剂量组及高剂量组之间治疗效果比较，差异无统计学意义（P＞0．05），但低剂量组不良反应发生相对轻微。结论口服普萘洛尔治疗IH安全有效。Objective To study the efficacy and adverse reactions of the treatment on different types of infantile hemangiomas （IH） with different doses of propranolol .Methods One hundred and fifty cases of IH without contraindications were randomly treated with different doses of propranolol （low dose group：1 mg·kg -1 ·d-1 ;high dose group：2 mg·kg -1 ·d-1 ） under ECG monitoring inferior half an hour to breastfeeding taking ,and stay in hospital for observation for 6 to 24 hours after the treatment . The patients returned to the hospital for review every month（ECG and blood RT ;lung function in necessary） .Results The curative effect is better on strawberry IH than that on flat IH ,also better on deeply IH than that on superficial IH .The adverse reactions oc‐curred relatively slight in the low dose group and there was no significantly statistical differences on the treatment effects between the both groups（P〉0 .05） .Conclusion It is safe and effective to treat IH with propranolol .

关 键 词：普萘洛尔 婴幼儿血管瘤 疗效 

分 类 号：R732.2[医药卫生—肿瘤]