术前介入化疗在宫颈癌Ⅱ期新辅助化疗中的应用  

Application of Preoperative Interventional Chemotherapy in Neoadjuvant Chemotherapy for Stage Ⅱ Cervical Carcinoma

作　　者：韦露薇[1] 

机构地区：[1]柳州市工人医院妇产科,广西柳州545005

出　　处：《实用临床医学（江西）》2014年第9期57-59,共3页Practical Clinical Medicine

摘　　要：目的：探讨介入化疗在宫颈癌Ⅱ期新辅助化疗中的临床应用价值。方法以58例宫颈癌Ⅱ期患者为研究对象。其中，31例适合介入治疗纳入介入化疗组，行超选插管化疗栓塞，10-14 d后，根据其疗效，行宫颈癌子宫广泛切除术＋盆腔淋巴结清扫术；28例不适合介入治疗患者纳入对照组，行单纯宫颈癌子宫广泛切除术。对比2组手术切除率、术中出血量和术后病理结果，并对其疗效进行评估。结果介入化疗组：30例有效，行子宫广泛切除术＋盆腔淋巴结清扫术；1例无效，行放射治疗。术中出血量、手术切缘阳性率、淋巴结转移率介入化疗组低于对照组（P〈0.05），3年和5年存活率介入化疗组高于对照组（P〈0.05）。结论子宫动脉化疗栓塞治疗是宫颈癌Ⅱ期术前新辅助化疗的有效辅助方法。Objective To investigate the value of preoperative interventional chemotherapy in neoadjuvant chemotherapy for stage Ⅱ cervical carcinoma. Methods Fifty-eighty patients with stage Ⅱ cervical carcinoma were divided into two groups. In interventional chemotherapy group（n=31 ）,pati ents received superselective chemoembolization, and underwent extensive uterus resection and pelvic lymphadenectomy after 10-14 days according to the curative efficacy of chemoembolization. In control group（n=28） ,patients only received extensive uterus resection. The resection rate, intraoperatve blood loss and postoperative pathological results were compared between the two groups. The curative efficacy was assessed in both groups. Results Among the 31 patients in interventional chemotherapy group, superselective chemoembolization was effective and extensive uterus resection and pelvic lymphadenectomy were performed in 30, and superselective chemoembolization was ineffective and radiotherapy was performed in 1. Compared with control group, intraoperatve blood loss, rate of positive surgical margins and rate of lymph node metastasis decreased while 3- and 5-year survival rates increased in interventional chemotherapy group （P〈0.05）.Conclusion Uterine artery chemoembolization is an effective auxiliary method in neoadjuvant chemotherapy for stage Ⅱ cervical carcinoma.

关 键 词：宫颈癌 新辅助化疗 化疗栓塞 

分 类 号：R737.33[医药卫生—肿瘤]