转移性乳腺癌患者血清CA15-3和CEA水平与临床病理参数的关系  

Relationships of Serum CA15-3 and CEA levels to Clinicopathological Parameters in Patients with Metastatic Breast Cancer

作　　者：耿彪[1] 梁曼曼[2] 赵文英[1] 叶晓兵[1] 

机构地区：[1]皖南医学院第一附属医院肿瘤内科,安徽芜湖241001 [2]皖南医学院第一附属医院感染性疾病科,安徽芜湖241001

出　　处：《南昌大学学报（医学版）》2014年第9期42-45,49,共5页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨转移性乳腺癌患者血清糖类抗原15-3(CA15-3)和癌胚抗原(CEA)水平与临床病理参数的关系。方法收集2007年1月至2012年12月皖南医学院第一附属医院收治的转移性乳腺癌患者284例,所有患者在诊断为转移性乳腺癌时,均检测血清CA15-3和CEA水平,统计分析血清CA15-3和CEA水平与患者临床病理参数的关系。结果 284例患者中,血清CA15-3高于正常水平者163例(57.4%),血清CEA高于正常水平者97例(34.2%)。血清CA15-3和CEA水平升高与乳腺癌分子分型有关(均P<0.05)。Luminal亚型患者血清CA15-3和CEA升高比例显著高于HER2-enriched亚型及TN亚型。血清CA15-3升高与骨转移有关(P<0.05),而血清CEA升高与转移部位无关。多处转移的患者血清CA15-3升高比例高于单处转移的患者(P<0.05),而血清CEA升高比例在单处转移的患者和多处转移的患者无明显差异(P>0.05)。结论转移性乳腺癌患者中,CA15-3、CEA升高与乳腺癌分子亚型显著相关,骨转移的患者CA15-3升高比例高于其他转移部位,而CEA升高与转移部位无关。多处转移的患者CA15-3升高比例高于单处转移的患者。Objective To investigate the relationships between serum carbohydrate antigen 15-3（CA15-3）and carcinoembryonic antigen（CEA）levels and clinicopathological parameters in pa-tients with metastatic breast cancer（MBC）.Methods Data of 284 MBC patients treated in the First Affiliated Hospital of Wannan Medical College between January 2007 and December 2012 were collected.Serum CA15-3 and CEA levels were measured when they were diagnosed as having MBC.The relationships between serum CA15-3 and CEA levels and clinicopathological parame-ters were analyzed.Results Of the 284 patients,elevated serum CA15-3 and CEA levels were i-dentified in 163（57.4%）and 97（34.2%）,respectively.The elevated serum CA15-3 and CEA lev-els were significantly associated with breast cancer molecular subtypes（P 〈0.05）.The percentage of patients with elevated serum CA15-3 and CEA levels among patients with luminal subtypes was higher than that among patients with HER2-enriched and TN subtypes.The elevated serum CA15-3 levels were correlated with bone metastasis（P 〈0.05）.However,the elevated serum CEA levels were not correlated with the sites of metastasis.The percentage of patients with elevated serum CA15-3 levels among patients with multiple metastases was higher than that among pa-tients with single metastasis（P 〈0.05）.There was no significant difference in the incidence of se-rum CEA elevation between patients with single metastasis and patients with multiple metastases （P 〉0.05）.Conclusion The elevated CA15-3 and CEA levels are associated with breast cancer molecular subtypes in patients with MBC.The percentage of patients with elevated serum CA15-3 levels among patients with bone metastasis is higher than that among patients with other metasta-sis,and that among patients with multiple metastases is higher than that among patients with sin-gle metastasis.The elevated CEA levels are not correlated with the sites of metastases.

关 键 词：转移性乳腺癌 糖类抗原15-3 癌胚抗原 临床病理参数 

分 类 号：R737.9[医药卫生—肿瘤] R446.1[医药卫生—临床医学]