针刺疗法对中国人群老年性痴呆效果的系统评价和Meta分析  

Systematic Review and Meta-analysis on Acupuncture for Alzheimer Disease in Chinese Population

作　　者：曹飞[1] 潘小玲[2] 李譞超[1] 陈宝[1] 金媛[1] 黄鹏[3] 

机构地区：[1]南昌大学研究生院医学部,2012级南昌330006 [2]南昌大学期刊社,南昌330006 [3]南昌大学公共卫生学院流行病学教研室,南昌330006

出　　处：《南昌大学学报（医学版）》2014年第9期59-61,65,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的系统评价针刺疗法对中国人群老年性痴呆(AD)的效果,为AD治疗提供更可靠的信息。方法收集1979年1月至2013年12月国内外公开发表的关于中国人群AD针刺治疗的资料,评价针刺对患者认知功能(MMSE)和日常生活活动能力(ADL)的影响,并使用RevMan5.0软件进行Meta分析。结果共纳入5篇关于针刺治疗的文献,对照均为口服常规药物。在患者认知功能方面,WMD及其95%的可信区间为-0.61(-1.34、0.13);在患者ADL方面,WMD及其95%的可信区间为-0.48(-0.72、0.76)。结论与口服常规药物比较,针刺治疗AD在MMSE评分及ADL评分方面无明显改善,且纳入的研究质量均较差,针刺的效果尚需更多观察。Objective To assess the therapeutic effect of acupuncture on Alzheimer disease （AD）in Chinese population,and to provide more reliable information for the treatment of AD. Methods The literature published from January 1979 to December 2013 on the acupuncture for treatment of Alzheimer disease in Chinese population was collected,and the effects of acupuncture on mini-mental state examination（MMSE）and activity of daily living（ADL）were assessed.The meta-analysis was conducted by using RevMan5.0.Results A total of 5 randomized controlled trials were identified and all controls were oral medications.In the aspect of cognitive function,the weighted mean difference（WMD）was -0.61 （- 1.34,0.13）.In the aspect of ADL,the WMD was -0.48（-0.72,0.76）.Conclusion Compared with oral medications,the acupuncture can not improve the MMSE and ADL scores in patients with AD.Furthermore,the quality of literature is poor.Therefore,more observations are needed to verify the effect of acupuncture on AD.

关 键 词：老年性痴呆 针刺疗法 系统评价 META 分析 简易精神状态检查表 日常生活能力量表 

分 类 号：R74[医药卫生—神经病学与精神病学] R245[医药卫生—临床医学]