奥氮平联合氟西汀对精神分裂症患者心理健康状况的影响  

The influence of olanzapine combined with fluoxetine on mental health status of schizophrenics

作　　者：杨立身[1] 段加艳 周树南[1] 

机构地区：[1]云南省心理卫生中心,云南昆明650301

出　　处：《临床心身疾病杂志》2014年第6期59-61,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 探讨奥氮平联合氟西汀对精神分裂症患者心理健康状况的影响.方法 将43例精神分裂症患者随机分为两组,均予以奥氮平治疗,研究组在此基础上联合氟西汀治疗.观察12周.采用症状自评量表评定心理健康状况.结果 治疗后两组总有效率比较差异无显著性（P＞0.05）;研究组症状自评量表的躯体化、强迫、抑郁、恐怖因子分显著低于对照组（P＜0.05或0.01）,精神病性因子分显著高于正常成人常模（P＜0.01）.结论 奥氮平联合氟西汀能显著改善精神分裂病患者的心理健康状况,优于单用奥氮平治疗.Objective To explore the influence of olanzapine combined with fluoxetine on mental health status of schizophrenics. Methods Forty-three schizophrenics were randomly assigned to two groups treated with olanzapine, on this basis research group was plus fluoxetine for 12 weeks. Mental health status was assessed with Symptom Checklist-90 （SCL-90）. Results There was no significant difference in total effective rate （P〉0.05）; somatization, obsession, depression and phobia score of the SCL-90 were significantly lower （P〈0.05 or 0.01） and psychotic higher （P〈0.01） compared with normal adult norm. Conclusion Olanzapine combined with fluoxetine could effectively improve schizophrenics＇ mental health status compared with single olanzapine in the treatment of schizophrenia.

关 键 词：精神分裂症 心理健康 奥氮平 氟西汀 阳性与阴性症状量表 症状自评量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R395[医药卫生—临床医学]