阿立哌唑对晚发性精神分裂症患者认知功能的影响  

The influences of aripiprazole on cognitive function of patients with late schizophrenia

作　　者：余寒[1] 龙珊珊[1] 

机构地区：[1]自贡市精神卫生中心,四川自贡643000

出　　处：《临床心身疾病杂志》2014年第6期62-63,66,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 探讨阿立哌唑对晚发性精神分裂症患者认知功能的影响.方法 将106例晚发性精神分裂症患者随机分为两组,每组53例,分别口服阿立哌唑、氯丙嗪治疗.观察8周.于治疗前后采用阳性与阴性症状量表、威斯康星卡片分类测验评定临床疗效及认知功能.结果 治疗后两组阳性与阴性症状量表评分均较治疗前显著降低（P＜0.01）,阿立哌唑组威斯康星卡片分类测验的总正确数、持续反应数、完成分类数均较治疗前显著升高（P＜0.01）,总错误数、持续错误数均较治疗前显著降低（P＜0.01）,氯丙嗪组仅持续反应数较治疗前显著升高（P＜0.01）.结论 阿立哌唑治疗晚发性精神分裂症疗效显著,能显著改善患者认知功能.Objective To explore the influences of aripiprazole on cognitive function of patients with late schizophrenia. Methods A total of 106 patients with late schizophrenia were randomly divided into two groups （both n= 53） taking orally aripiprazole and chlorpromazine respectively for 8 weeks. Efficacies were assessed with the Positive and Negative Syndrome Scale （PANSS） and cognitive functions with the Wisconsin Card Sorting Test （WCST） before and after treatment. Results Compared with pretreatment post-treatment PANSS scores of both groups lowered more significantly （P〈0.01）, the number of total corrects, perseverative responses and categories completed heightened （P〈0.01） and the number of total errors and perseverative errors decreased （P〈0.01） in aripiprazole group, only perseverative responses heightened in chlorpromazine group （P〈0.01）. Conclusion Aripiprazole has an evident effect on late schizophrenia and could significantly improve patients＇ cognitive function.

关 键 词：晚发性精神分裂症 阿立哌唑 氯丙嗪 认知功能 临床疗效 阳性与阴性症状量表 威斯康星卡片分类测验 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.053[医药卫生—临床医学]