多西他赛联合洛铂治疗鼻咽癌肺转移的疗效初探  

Clinical efficacy of docetaxel combined with lobaplatin for the treatment of pulmonary metastasis of nasopharyngeal carcinoma

作　　者：张帅[1] 林少民[1] 孔飞[1] 

机构地区：[1]海南省人民医院放疗科,海南海口570311

出　　处：《海南医学》2014年第22期3317-3319,共3页Hainan Medical Journal

基　　金：海南省自然科学基金(编号:805102)

摘　　要：目的评价多西他赛联合洛铂治疗鼻咽癌肺转移的近期疗效及其毒性反应。方法 2009年9月至2012年7月我院共收治鼻咽癌肺转移患者24例,其中首程鼻咽癌肺转移5例,经放化疗后发生肺转移19例。多西他赛75 mg/m^2,静脉滴注,第1天;洛铂30 mg/m^2,静脉滴注,第1天,每3-4周重复化疗。连用两个周期后行胸部CT检查评价疗效,化疗期间常规复查血常规及肝肾功能,并观察其他毒副反应。结果多西他赛联合洛铂方案的总有效率为70.8%,疾病控制率为87.5%,毒副作用较轻,主要表现为骨髓抑制如粒细胞减少、贫血及血小板减少。结论多西他赛联合洛铂治疗鼻咽癌肺转移的近期疗效满意,且具有应用简便、毒副反应较轻的优点。Objective To evaluate the efficacy and toxicity of docetaxel combined with lobaplatin for the treatment of pulmonary metastasis of nasopharyngeal carcinoma. Methods Twenty-four patients with pulmonary metastasis of nasopharyngeal carcinoma admitted from Sep. 2009 to Jul. 2012 were enrolled in the study, including 5 cases of initial pulmonary metastasis and 19 cases of pulmonary metastasis after chemoradiotherapy. Docetaxel（75 mg/m^2） was given on the first day. Lobaplatin（30 mg/m^2） was given in the similar way. The courses were repeated every 3-4 weeks. After completing the above regimen, computed tomography（CT） was taken to find the changes in pulmonary metastasis. Regular review of blood and liver and kidney function was performed, and other toxicities were observed. Results The total effective rate of docetaxel combined with lobaplatin was 70.8%, and the disease control rate was 87.5%, with light side effects, mainly myelosuppression（such as neutropenia, anemia and thrombocytopenia）. Conclusion Docetaxel combined with lobaplatin has favourable outcomes for the treatment of pulmonary metastasis in nasopharyneal carcinoma. It is a convenient regimen with mild toxicity.

关 键 词：鼻咽癌 肺转移 化疗 洛铂 多西他赛 

分 类 号：R739.63[医药卫生—肿瘤]