免疫固定电泳对多发性骨髓瘤的诊断价值  

Diagnostic value of immunofixation electrophoresis on multiple myeloma

作　　者：廖君群[1] 杨清秀[2] 毕小云[1] 

机构地区：[1]重庆医科大学附属第一医院检验科,重庆400016 [2]重庆医科大学,重庆400016

出　　处：《检验医学与临床》2014年第22期3092-3093,3096,共3页Laboratory Medicine and Clinic

基　　金：国家临床重点专科建设项目(财社[2010]305号)

摘　　要：目的探讨免疫固定电泳(IFE)在多发性骨髓瘤(MM)诊断中的价值。方法采用法国Sebia公司生产的Hydarsys 2琼脂糖凝胶电泳仪,对临床上有检测需求的患者血清进行IFE,并回顾性分析其相关实验室检查资料。结果 155例患者的血清IFE检测结果中,67例阳性,其中经临床诊断证实的MM 51例。IFE对MM诊断的灵敏度和特异度分别为69.9%、80.5%。51例IFE阳性的MM患者中,以免疫球蛋白(Ig)Gκ型和λ型为主,分别占19.61%、27.45%,但其余各型均有分布。51例IFE阳性MM患者病例资料回顾性分析结果显示,由于原发疾病被贫血、骨痛等首发症状掩盖,患者常会就诊于其他科室。结论 IFE对MM的准确诊断、疗效监测、预后判断具有重要的临床意义。Objective To evaluate the value of immunofixation electrophoresis（IFE）in the diagnosis of multiple myeloma（MM） .Methods The Sebia Hydrasys 2 agarose electrophoresis apparatus made byFrance was adopted to perform IFE on the serum samples in the patients with the clinical IFE detection demand .The related laboratory detection data of these patients were retrospectively analyzed .Results Among 155 cases of IFE detection results ,67 cases were positive ,in which 51 cases of MM were verified by clinical diagnosis .The sensitivity and specificity of IFE for diagnosing MM were 69 .9% and 80 .5% respectively .In 51 cases of MM ,IgG kappa type and IgG lambda type were predominant ,accounting for 19 .61% and 27 .45% ,respectively ,but the other types had distribution .The retrospective analysis results of the medical record data in 51 cases of MM and positive IFE showed that the patients often visited to other departments because the primary disease was covered with the initial symptoms such as anemia ,bone pain .Conclusion IFE has important clinical significance for accurately diagnosing MM ,monitoring the curative effect and judging prognosis .

关 键 词：多发性骨髓瘤 免疫固定电泳 M蛋白 

分 类 号：R733.3[医药卫生—肿瘤]