Effect of temperature on noninvasive blood glucose monitoring in vivo using optical coherence tomography  

作　　者：苏亚 孟卓 王龙志 于海民 刘铁根 

机构地区：[1]Polarization Research Center, College of Precision Instrument & Opto-electronics Engineering and Key Laboratory of Opto-electronics Information and Technical Science,Ministry of Education, Tianjin University [2]Suzhou Opto-ring Co. Ltd. [3]College of Automobile and Transportation, Tianjin University of Technology and Education

出　　处：《Chinese Optics Letters》2014年第11期70-74,共5页中国光学快报（英文版）

基　　金：supported by the National"973"Program of China(No.2010CB327806);the International Science&Technology Cooperation Program of China(No.2010DFB13180);the Medical Instruments and New Medicine Program of Suzhou(No.ZXY2012026);the Foundation Research Project of Jiangsu Province(No.BK20130374)

摘　　要：Noninvasive glucose monitoring（NIGM） techniques based on optical coherence tomography（OCT） are affected by several perturbing factors, including variation of tissue temperature. We first design a temperature control module integrated with an optical scanning probe to precisely control the temperature of skin tissues. We investigate the influence of temperature on NIGM with OCT by correlation analysis at different depths of in vivo human skin. On average, the relative changes in attenuation coefficient（ μt） per 1 °C of temperature lead to 0.30 ± 0.097 mmol/L prediction error of blood glucose concentration. For NIGM measurement methods using optical properties of the tissues, this effect can be taken into account.Noninvasive glucose monitoring（NIGM） techniques based on optical coherence tomography（OCT） are affected by several perturbing factors, including variation of tissue temperature. We first design a temperature control module integrated with an optical scanning probe to precisely control the temperature of skin tissues. We investigate the influence of temperature on NIGM with OCT by correlation analysis at different depths of in vivo human skin. On average, the relative changes in attenuation coefficient（ μt） per 1 °C of temperature lead to 0.30 ± 0.097 mmol/L prediction error of blood glucose concentration. For NIGM measurement methods using optical properties of the tissues, this effect can be taken into account.

关 键 词：BLOOD GLUCOSE HISTOLOGY Optical properties SKIN Temperature control Tissue 

分 类 号：R197.39[医药卫生—卫生事业管理]