121例椎-基底动脉延长扩张症患者不同临床特征系统分析  

Systematic Analysis and Investigation of Different Clinical Features about Vertebrobasilar Dolichoectasia:Reports of 121 Cases

作　　者：李黎光[1] 张信芳[1] 刘轶丹[1] 钟凯[1] 刘学文[1] 

机构地区：[1]辽宁医学院附属第一医院神经内科,辽宁锦州121001

出　　处：《中国医科大学学报》2014年第11期1003-1007,1014,共6页Journal of China Medical University

基　　金：辽宁省自然科学基金(2014022030)

摘　　要：目的分析并探讨椎-基底动脉延长扩张症(VBD)患者的临床特征表现。方法回顾性系统分析2011年1月至2013年12月在辽宁医学院附属第一医院神经内科住院确诊的121例VBD患者的临床资料,并深入比较症状性与非症状性VBD患者的各项影响因素以及血管性症状和无血管性症状的VBD患者间的差异。结果症状性VBD与非症状性VBD患者的基础数据相比较,症状性VBD患者的基底动脉直径显著大于非症状性VBD患者(P<0.05),症状性VBD患者的高血压病史、舒张压、尿酸水平均较非症状性VBD患者显著增高(P<0.05);存在血管性症状的患者基底动脉直径显著大于无血管性症状者(P<0.05),同时血管性症状患者的基线收缩压、舒张压均显著高于无血管性症状者(P<0.05),其既往高血压病史的发生率也显著多于无血管性症状者(P<0.05)。结论对于VBD患者应在早期严格控制血压,可能有利于延缓症状(尤其是血管性症状)的进展及降低症状的发生率,对尿酸增高的VBD患者可能考虑通过降尿酸达到治疗的目的。Objective To analyze and investigate the clinical features and manifestations of vertebrobasilar dolichoectasia （VBD） patients.Methods The clinical data of VBD patients who were diagnosed in department of neurology of the first affiliated hospital of Liaoning medical university from 2011 January to 2013 December was analyzed systematically and retrospectively.The thorough comparison of all influencing factors between symptomatic VBD and asymptomatic VBD inpatients was performed.The difference of symptoms of vascular was compared between VBD inpatients and no vascular symptoms VBD inpatients.Results The basal artery diameter of symptomatic VBD inpatients was significantly greater than the basal artery diameter of asymptomatic VBD inpatients （P ＜ 0.05）.The rate of hypertension and diastolic blood pressure and the level of uric acid were higher compared to asymptomatic VBD inpatients in symptomatic VBD inpatients （P ＜ 0.05）.The basal artery diameter of symptoms of vascular VBD inpatients was significantly greater than the no vascular symptoms VBD inpatients; meanwhile,the baseline systolic blood pressure and the diastolic blood pressure of symptoms inpatients was significantly higher than that of no vascular symptoms VBD inpatients （P ＜ 0.05）.The incidence of hypertension about symptoms of vascular VBD inpatients was significantly higher than that of no vascular symptoms VBD inpatients （P ＜ 0.05）.Condusion It is possible to delay the progress of symptoms （especially symptoms of vascular VBD inpatients） and decrease the rate of symptoms if blood pressure is controlled strictly at the early stage of VBD and the therapeutic purpose may be reached by reducing uric acid for hypeluricemia VBD inpatients.

关 键 词：椎-基底动脉延长扩张症 临床特征 高血压 

分 类 号：R743.4[医药卫生—神经病学与精神病学]