脑血管病急性期MMP-9、IL-6和IL-10水平变化的研究  

MMP-9,IL-6 and IL-10 levels in acute cerebrovascular disease

作　　者：张丽丽[1] 王会奇[1] 脱厚珍[1] 冯子敬[1] 王佳伟[1] 李继梅[1] 张拥波[1] 王得新[1] 

机构地区：[1]首都医科大学附属北京友谊医院神经内科

出　　处：《中国神经免疫学和神经病学杂志》2014年第6期407-409,413,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：国家自然科学基金资助项目(81241039);科技新星计划项目(2005B42)

摘　　要：目的探讨基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)与脑动脉粥样硬化斑块不稳定性以及脑梗死的关系。方法选择急性脑血管病患者56例,其中反复短暂性脑缺血发作(TIA)16例,急性脑梗死40例。对照组为21例健康体检者。所有缺血性脑血管病患者均经头CT血管造影(CTA)检查或颈部血管超声证实存在不稳定斑块,且发病机制考虑与不稳定斑块破裂有关。采用ELISA方法检测各组血清MMP-9、IL-6和IL-10水平并进行比较。结果急性脑梗死组患者血清中MMP-9、IL-10水平分别为(137.10±69.38)ng/mL和(39.16±32.82)pg/mL,TIA组患者血清中MMP-9、IL-10水平分别为(119.79±65.54)ng/mL和(33.00±21.36)pg/mL,均明显高于对照组〔分别为(65.42±36.81)ng/mL和(19.83±12.16)pg/mL〕;脑梗死组患者血清MMP-9及IL-10水平均高于TIA组(均P<0.05)。各组间IL-6水平差异无统计学意义(均P>0.05)。结论 MMP-9和IL-10水平升高可能与动脉粥样硬化不稳定斑块破裂以及脑梗死灶形成有关。Objective To investigate the relationship between matrix metalloproteinase-9（MMP-9）,interleukin-6（IL-6）,interleukin-10（IL-10）and the stability of cerebral atherosclerotic plaque and cerebral infarction.Methods Serum of 56 patients with acute cerebral vascular diseases（including 16 repeated transient ischemic attack（TIA）and 40 acute cerebral infarction（ACI））,were collected within 3days of onset,all the patients were given examinations such as computed tomography angiography（CTA）or Doppler ultrasonography or magnetic resonance angiography（MRA）to investigate if there was unstable plaque.The control group includes 21 healthy volunteers.The levels of serum MMP-9,IL-6and IL-10 were detected using enzyme-linked immunosorbent assay（ELISA）in all the subjects.Results Patients with ACI and TIA had higher serum levels of MMP-9[（137.10±69.38）ng/mL and（119.79±65.54）ng/mLvs.（65.42±36.81）ng/mL,P〈0.05]and IL-10[（39.16±32.82）pg/mL and（33.00±21.36）pg/mL vs.（19.83±12.16）pg/mL,P〈0.05]than controls,there were also significant difference between the group ACI and TIA（P〈0.05）.But there was no significant difference between groups in IL-6 level（P〉0.05）.Conclusions MMP-9and IL-10 levels rise in the acute period of ACI and TIA,suggesting that it may be related with the rupture of unstable plaque.

关 键 词：不稳定斑块 基质金属蛋白酶-9 白细胞介素-6 白细胞介素-10 

分 类 号：R743.3[医药卫生—神经病学与精神病学]