中药生物药剂学分类系统中多成分环境对葛根素溶解度的影响  

Impacts of multicomponent environment on solubility of puerarin in biopharmaceutics classification system of Chinese materia medica

作　　者：侯成波[1] 汪国鹏 张强[1] 杨文宁[1] 吕贝然[1] 隗丽[1] 董玲[1] 

机构地区：[1]北京中医药大学,北京100102 [2]中财瀚熙(北京)生物科技发展有限公司,北京100055

出　　处：《中国中药杂志》2014年第23期4499-4504,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81473362);北京中医药大学创新团队发展计划项目(2011-CXTD-13)

摘　　要：该研究针对中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的溶解度问题,实验考察人工制造的多成分环境对溶解度的影响,并利用所获数据进行数学建模总结相关规律。实验采用递进式设计,分别研究了单一成分背景(黄芩苷、小檗碱和甘草酸)、两成分背景(黄芩苷+甘草酸、黄芩苷+小檗碱和甘草酸+小檗碱)和三成分背景(黄芩苷+甘草酸+小檗碱)对葛根素溶解度影响的变化趋势,从而建立多成分环境对葛根素溶解度影响的数学回归模型方程。To illustrate the solubility involved in biopharmaceutics classification system of Chinese materia medica （CMMBCS）, the influences of artificial muhicomponent environment on solubility were investigated in this study. Mathematical model was built to describe the variation trend of their influence on the solubility of puerarin. Carried out with progressive levels, single component environment： baicalin, berberine and glycyrrhizic acid; double-component environment： baicalin and glycyrrhizic acid, baicalin and berberine and glycyrrhizic acid and berberine; and treble-component environment： baicalin, berberin, glycyrrhizic acid were used to describe the variation tendency of their influences on the solubility of puerarin, respectively. And then, the mathematical regression equation model was established to characterize the solubility of puerarin under muhicomponent environment.

关 键 词：中药生物药剂学分类系统 多成分环境 溶解度 葛根素 数学建模 

分 类 号：R284[医药卫生—中药学]