粉体表面改性技术改善中药浸膏粉流动性的研究  

Research about improving flowability of powder of Chinese herbs extracts by surface modification technology

作　　者：余艳宏[1] 陆文亮[2,3] 李佳佳[1] Changquan Calvin Sun 周群[1] 

机构地区：[1]华中科技大学同济医学院药学院,湖北武汉430030 [2]天津天士力控股集团有限公司研究院,天津300410 [3]天津中医药大学药学院,天津300193 [4]美国明尼苏达大学药学院药剂系材料与工程实验室,美国55455

出　　处：《中国中药杂志》2014年第23期4590-4595,共6页China Journal of Chinese Materia Medica

摘　　要：该研究应用粉体表面改性技术改善中药浸膏粉的流动性。应用Comil粉碎整粒机,将1%的纳米Si O2对7种中药浸膏粉进行表面改性处理。采用粉体流动性测试仪,比较改性处理前后各浸膏粉的流动性变化,利用扫描电镜(SEM)观察各浸膏粉的微观表面形态变化,借助显微镜测定并比较各浸膏粉的粒径分布变化,并对改性前后的浸膏粉进行吸湿性研究。结果表明,表面改性处理后,各浸膏粉的休止角、抹刀角、压缩度、黏附度均明显降低,流动性指数增加,流动性得到显著性提高,以葛根浸膏粉和大黄浸膏粉改善最为显著,扫描电镜观察显示改性后的浸膏粉表面均附着有纳米Si O2,而改性前后的浸膏粉的粒径和吸湿性均无明显变化。该技术可为改善中药浸膏粉流动性提供新的解决途径。In this study, modification technology by surface coating was used to improve the flowability of powder of Chinese herbs extracts. Seven kinds of powder of Chinese herbs extracts were coated with 1% silica nanoparticles using an under-driven Comil. The powder characteristics tester was used to evaluate the flowability of uncoated and coated powders. Surface morphology and particle size distribution of powders were compared by scanning electron microscope （SEM）and optical microscope. The powder hygroscopicity was also investigated. The results showed that, after modification, angle of repose, angle of spatula, compressibility and adhesiveness extremely decreased, and flowability index substantially increased, the powder flowability was significantly improved, especially Gegen and Dahuang extracts powders. Scanning electron microscopy images showed the distribution of silica nanoparticles on the host drug particle surfaces. There were no remarkable changes in the particle size distribution and hygroscopicity of all powders after coating. Therefore, Comilling for surface coating modification technology was an effective method to improve the flowability of Chinese herbs ex- tracts and suggested a possible way forward to enhance the quality of Chinese drugs pharmaceutics in their study and manufacture.

关 键 词：中药浸膏粉 表面改性 Comil粉碎整粒机 流动性 

分 类 号：R283[医药卫生—中药学]