溶剂挥发法制备噻唑磷微胶囊  

Preparation Microcapsules Containing Nemathorin with Solvent Evaporation Method

作　　者：王子希 宋思思[1,2] 李晓刚[1,2] 

机构地区：[1]湖南农业大学植物保护学院,湖南长沙410128 [2]湖南省生物农药与制剂加工工程技术研究中心,湖南长沙410128

出　　处：《广东化工》2014年第22期22-23,11,共3页Guangdong Chemical Industry

基　　金：湖南省自然科学基金(13JJ5023);湖南省高等学校科学研究重点项目(11A053);中国烟草总公司科技重点项目计划(110201302014)

摘　　要：制备基于聚乳酸(PLA)改性聚丁二酸丁二醇酯(PBS)为载体的噻唑磷微胶囊。采用溶剂挥发法以聚乙烯醇-1788为乳化分散剂制备微胶囊,通过激光粒度分析仪、光学显微镜、扫描电镜对微胶囊进行形貌表征,用紫外分光光度计研究微胶囊的缓释行为。经聚乳酸(PLA)共混改性后的PBS载体微胶囊的包封率为85.27%、载药量为61.64%,平均粒径为5.46μm,缓释期为30 d。改性后的微胶囊具有较好的形貌,载药量和包封率比纯PBS载体微胶囊高,药物缓释更长。The microcapsules containing thiamethoxam were prepared with poly（butylene succinate） modified with poly lactic acid（PLA） as carrier. The microcapsules were prepared via emulsion solvent evaporation process, and PVA-1788 was used as emulsifier. The microcapsules were characterized through automatic laser granularity analyzer, optical microscope, scanning electron microscope. The released properties were studied via ultraviolet spectrophotometer. The encapsulation rates of modified PBS（prepared by melt-mixing with PLA） microcapsules were 80.53 %, the loading rates were 54.47 %, the average diameters were 4.83 μm, the release dates were 25 d. The modified PBS microcapsules had better surface topography and longer release dates, the encapsulation and loading rates were higher than pure PBS microcapsule.

关 键 词：噻唑磷 微胶囊 溶剂挥发法 聚丁二酸丁二醇酯 聚乳酸 

分 类 号：TQ460.4[化学工程—制药化工]