RIN1在人膀胱尿路上皮癌中的表达  

RIN1 expression in human bladder urothelial carcinoma

作　　者：单广夷[1] 付成[1] 陈昂[1] 胡滨[1] 毕缓[1] 

机构地区：[1]辽宁省肿瘤医院泌尿外科,辽宁沈阳110024

出　　处：《解剖科学进展》2014年第6期518-520,共3页Progress of Anatomical Sciences

摘　　要：目的研究RIN1在人膀胱尿路上皮癌中的表达。方法分别应用免疫蛋白印迹技术和实时定量PCR技术检测RIN1蛋白和RIN1 m RNA在人膀胱尿路上皮癌及癌旁组织中的表达。结果 Real-time PCR结果发现,在15对新鲜的膀胱尿路上皮癌及癌旁组织中,有12对的癌组织中RIN1表达高于癌旁组织。在膀胱尿路上皮癌组织中,RIN1的m RNA表达平均倍数为10.61±5.42,癌旁组织中,RIN1的m RNA平均倍数为4.31±1.77,P<0.05。Western blot法结果认证了RIN1在膀胱尿路上皮癌组织中的表达是升高的。结论 RIN1在膀胱尿路上皮癌组织中的m RNA和蛋白的表达水平高于癌旁组织。Objective To observe the expression of RIN1 in human bladder urothelial carcinoma. Methods The expression of RIN1 m RNA and protein in 15 cases of paired human bladder urothelial carcinoma and the paracancer normal tissues was detected by quantitative RT-PCR and Western blot respectively. Results The expression levels of RIN1 m RNA and protein were much higher in human bladder urothelial carcinoma tissues than in paracancer normal tissues.Conclusion RIN1 expression was up-regulated in bladder urothelial carcinoma.

关 键 词：RIN1 膀胱癌 尿路上皮癌 人 

分 类 号：R737.14[医药卫生—肿瘤]