KLFs与肿瘤发生发展的关系  

The relationship of KLFs with occurrence and development of tumor

作　　者：郑乐[1] 李天人[1] 郭科军[1] 

机构地区：[1]中国医科大学附属第一医院妇科,辽宁沈阳110001

出　　处：《解剖科学进展》2014年第6期585-587,591,共4页Progress of Anatomical Sciences

基　　金：沈阳市科技计划项目(F11-262-9-14)

摘　　要：Krüpple是果蝇分节基因"间隙基因"类的一个成员,它编码一个包含一个DNA结合序列的蛋白质,该序列由几个Cys2/His2型的锌指构成,一群与Krüpple的锌指结构高度同源的蛋白质被发现,命名为Krüpple样因子(Krüpple-like factor,KLFs),它们通过调控多种富含GC或CACCC的启动子的基因的表达,参与细胞增殖、分化、凋亡和肿瘤发生、发展等多种生理、病理过程。本文综述KLFs的结构、表达调控功能、主要家族成员及其在肿瘤研究中的现状,探讨其与肿瘤发生发展的关系。Krtipple is a member of the ＂gap gene＂, flies segmentation gene, encoding a DNA binding sequence protein, the sequence is composed of several Cys2 / His2 type zinc finger. A group of highly homologous proteins with zinc finger structure of Krtipple were named as Krtipple sample factor （Krfipple-like factor, KLFs）. They are involved in cell proliferation, differentiation, apoptosis and tumor occurrence, development and a variety of physiological and pathological process through regulating the expressions of rich containing GC or CACCC promoter genes. This review explores its relationship with the occurrence and development of tumor.

关 键 词：KLFs 分节基因 锌指结构 细胞增殖 结合序列 高度同源 启动子 SMAD 宫颈鳞癌 结构域 

分 类 号：R730.23[医药卫生—肿瘤]