乙二醛酶Ⅰ在肝再生中的作用研究进展  

Research progress of the role of glyoxalase I in liver regeneration

作　　者：耿小芳[1,2] 张富春[1] 马纪[1] 徐存拴 

机构地区：[1]新疆大学生命科学与技术学院新疆生物资源基因工程重点实验室,新疆乌鲁木齐8300462 [2]河南师范大学省部共建细胞分化调控国家重点实验室培育基地,河南新乡453007

出　　处：《基础医学与临床》2014年第12期1702-1705,共4页Basic and Clinical Medicine

基　　金：国家973前期研究专项资助项目(2012CB722304);河南省重大科技攻关项目(111100910600)

摘　　要：代谢产生的毒性物质甲基乙二醛(MG)可通过乙二醛酶系转化成非毒性物质D-乳酸。再生肝等正常生理性增生以及肝癌等病理性增生组织中,乙二醛酶Ⅰ(GLO1)的表达和活性增加,可提高肝脏的解毒能力和应激反应能力,促进肝细胞存活和增殖,保护肝脏细胞免受凋亡。The glyoxalase system catalyses the conversion of deleterious methylglyoxal （ MG）, mainly produced by glycolysis, to non-toxic d-lactate. Increased glyoxalase Ⅰ（GL01） expression or enzymatic activity level have been observed either in proliferating normal tissues such as regenerating liver, or in some proliferative disorders, including hepatocellular carcinoma, which can improve the ability of liver to detoxify and stress reaction, and promote hepatocyte survival and proliferation, and protect liver cells from apoptosis.

关 键 词：肝再生 甲基乙二醛 乙二醛酶Ⅰ 细胞存活与增殖 

分 类 号：R735.7[医药卫生—肿瘤]