遗忘型轻度认知障碍的脑白质纤维束成像研究  

Study of white matter tractography in patients with amnestic mild cognitive impairment

作　　者：吴娟[1] 顾红梅[1] 曹亮[1] 李敏达[1] 解骞[2] 唐颖[2] 张勤慧[1] 

机构地区：[1]南通大学附属医院放射科,江苏南通226001 [2]复旦大学附属华山医院放射科

出　　处：《实用放射学杂志》2014年第11期1787-1790,1801,共5页Journal of Practical Radiology

摘　　要：目的应用纤维束成像术研究遗忘型轻度认知功能障碍（aMCI）患者脑白质细微结构的改变。方法对30例经临床诊断的aMCI患者和31例正常对照（NC）组行扩散张量成像，用dTV11软件重建出扣带束、胼胝体、钩状束及下枕额束，并沿着白质束测量部分各向异性（FA）值。对比分析aMCI组与NC组各白质束的FA值，并将aMCI组的FA值与简易智能精神状态检查量表（MMSE）评分进行相关性分析。结果①aMCI组的两侧扣带束、两侧钩状束及胼胝体FA值明显低于NC组，差异有统计学意义；左侧下枕额束FA值低于NC组，但差异无统计学意义。②右侧扣带束的FA值与MMSE评分呈正相关。结论aMCI患者扣带束、钩状束及胼胝体FA值的异常改变，提示在阿尔茨海默病（AD）的前驱阶段存在与记忆相关的脑白质束的微损害，纤维束成像（tractography）技术对脑白质的早期损害具有很高的敏感性。Objective To investigate subtle structural changes of white matter in patients with amnestic mild cognitive impairment （aMCI） using a traciography-based method. Methods Thirty patients with clinical diagnosis of aMCI and thirty-one cases of normal control （NC） and undergone diffusion tensor imaging. Cingulum （CG）, corpus callosum （CC）, uncinate fasciculus （UNC） and inferior occipitofrontal fasciculus （IOFF） were reconstructed, and fractional anisotrophy （FA） values were measured along these tracts using dTV II software. Differences of white matter tracts＇ FA values were explored between aMCI group and NC group. In addition, correlation analyses were also done between FA values and the MMSE（ mini-mental state examination） scores in the aMCI patients. Results ① aMCI patients exhibited significant lower FA values in the bilateral CG, bilateral UNC and CC than NC group. Although there were no statistically significant differences, aMCI patients exhibited lower FA values than NC group in the left IOFF. ② The FA values of right CG were positively correlated with MMSE scores. Conclusion Abnormal changes of FA values in CG, UNC and CC of aMCI patients suggest that subtle damages of white matter tracts related to memory exist in the prodromal phase of Alzheimer＇s disease （AD）. Fiber tracrography has high sensitivity in detecting early damages of white matter.

关 键 词：脑 认知障碍 磁共振成像 扩散张量成像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]