MRI增强后扩散加权成像鉴别乳腺良恶性肿瘤临床应用研究  

Evaluation of diffusion weighted imaging after contrast in characterizing breast tumors

作　　者：黄娟[1] 田军章[1] 江桂华[1] 曾少庆[1] 马晓芬[1] 李武铭[1] 

机构地区：[1]广东省第二人民医院影像科,广东广州510317

出　　处：《实用放射学杂志》2014年第11期1831-1834,共4页Journal of Practical Radiology

摘　　要：目的评估乳腺疾病患者中钆对比剂对MRI扩散加权成像（DWI）和病变的表观扩散系数（ADC）是否有显著性影响，分析增强前后ADC值在乳腺良恶性病变鉴别中的价值。方法收集本院行乳腺MRI检查的35例患者共计38个病灶，所有病灶均经病理证实。笔者对比了增强前后正常乳腺组织及病灶的信噪比（SNR）和对比噪声比（CNR），以及病灶增强前后的ADC值。结果（1）增强前后DWI的SNR及CNR无统计学差异；（2）恶性病灶增强前后的ADC值存在统计学差异，增强前后ADC值平均降幅11．6％；良性病灶增强前后的ADC值无统计学差异。结论增强后ADC值能够更好地反映乳腺病变的恶性潜能。Objective To evaluate the effect of intravenous administration of gadolinium-DTPA on diffusion weighted imaging （DWI） of breast lesions and apparent diffusion coefficient（ ADC） values, and to evaluate the diagnostic performance of post-contrast ADC for differentiating benign from malignant lesions in breast. Methods Thirty-eight histopathologically-confirmed breast lesions were analyzed. We examined the signal to noise ratio（SNR） of normal breast tissue and lesions and evaluated the contrast to noise ratio（CNR） of each lesion. We also assessed the relation between pre-and post-contrast ADC values. Results SNRs and CNRs of DWI before and after contrast were not significantly different. The mean post-contrast ADC values for malignant lesions significantly decreased after contrast injected （mean of -11.6 %）, while ADC values in the benign lesions were not significantly different before and after contrast. Conclusion Post-contrast ADC values may be a better indicator of potential breast tumors than pre-contrast ADC values.

关 键 词：乳腺癌 扩散加权成像 表观扩散系数 钆喷酸葡胺 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]