药物性牙龈增生与胶原代谢失衡的相关性研究进展  

Research progress of the correlation between collagen metabolic imbalance and drug-induced gingival overgrowth

作　　者：李午丽[1] 赵守亮[1] 

机构地区：[1]同济大学附属口腔医院牙体牙髓科,口腔生物医学及转化医学实验室,上海200072

出　　处：《牙体牙髓牙周病学杂志》2014年第11期681-684,共4页Chinese Journal of Conservative Dentistry

基　　金：国家自然科学基金面上项目(81170951)

摘　　要：药物性牙龈增生(drug-induced gingival overgrowth,DIGO)是指长期服用某些特定药物而引起的牙龈纤维性增生和体积增大,其发病机制尚不清楚。目前研究表明,胶原的合成和降解失衡与药物性牙龈增生有密切关系。本文就药物性牙龈增生与胶原代谢失衡的相关研究进展作一综述。Patients who have undergone long-term treatment with certain drugs often suffer from drug-induced gingival overgrowth（ DIGO）. The pathogenesis of DIGO is not well understood. The imbalance of collagen production and collage degradation is proved to be related to the development of DIGO. The progress on the relationship between DIGO and collagen metabolism is reviewed in this paper.

关 键 词：药物性牙龈增生 胶原代谢 胶原吞噬 胶原降解 基质金属蛋白酶 

分 类 号：R781.4[医药卫生—口腔医学]